Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment
Combined vaccines containing non-cellular pertussis component and having low reactogenicity, increase vaccination coverage against controllable infections. However, the safety of vaccination in children dealing with health issues, as well as those having a history of premature infancy, requires addi...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2015-08-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/704 |
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| author | D. А. Novikova L. S. Namazova-Baranova А. G. Gayvoronskaya М. I. Broeva М. V. Fedoseenko |
| author_facet | D. А. Novikova L. S. Namazova-Baranova А. G. Gayvoronskaya М. I. Broeva М. V. Fedoseenko |
| author_sort | D. А. Novikova |
| collection | DOAJ |
| description | Combined vaccines containing non-cellular pertussis component and having low reactogenicity, increase vaccination coverage against controllable infections. However, the safety of vaccination in children dealing with health issues, as well as those having a history of premature infancy, requires additional research. The article presents reactogenicity analysis for the DTP-IPV/HIB pentavaccine during primary vaccination and revaccination of premature infants (n = 85), as well as vaccination of mature newborns (n = 1433) inoculated in accordance with the national Vaccination Calendar behind the schedule. The occurrence of post-vaccinal reactions in the premature infant group was the same as in the mature infant group and amounted to 41.2% and 45.0%; the occurrence of common reactions was 18.8% and 22.4%; local effects measured 25.8% and 27.9% respectively. Post-vaccinal reactions were either weak or moderate, not requiring treatment, and they would completely disappear by the end of the third post-vaccinal day. Simultaneous injection of pentavaccine and Hepatitis B vaccine and pneumococcal conjugate vaccine in children with a history of premature infancy, showed no influence during the post-vaccinal period. The reactogenicity of pentavaccine increased along with the vaccination ratio during the primary series of vaccinations. |
| format | Article |
| id | doaj-art-4f27549a03874a2bb3c8afd88961eb5b |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-4f27549a03874a2bb3c8afd88961eb5b2025-08-20T03:21:14Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352015-08-0114339239510.15690/vsp.v14i3.1376704Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s ExperimentD. А. Novikova0L. S. Namazova-Baranova1А. G. Gayvoronskaya2М. I. Broeva3М. V. Fedoseenko4Scientific Centre of Children Health, Moscow, Russian FederationScientific Centre of Children Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Russian Federation Pirogov Russian National Research Medical University, Moscow, Russian FederationScientific Centre of Children Health, Moscow, Russian FederationScientific Centre of Children Health, Moscow, Russian FederationScientific Centre of Children Health, Moscow, Russian FederationCombined vaccines containing non-cellular pertussis component and having low reactogenicity, increase vaccination coverage against controllable infections. However, the safety of vaccination in children dealing with health issues, as well as those having a history of premature infancy, requires additional research. The article presents reactogenicity analysis for the DTP-IPV/HIB pentavaccine during primary vaccination and revaccination of premature infants (n = 85), as well as vaccination of mature newborns (n = 1433) inoculated in accordance with the national Vaccination Calendar behind the schedule. The occurrence of post-vaccinal reactions in the premature infant group was the same as in the mature infant group and amounted to 41.2% and 45.0%; the occurrence of common reactions was 18.8% and 22.4%; local effects measured 25.8% and 27.9% respectively. Post-vaccinal reactions were either weak or moderate, not requiring treatment, and they would completely disappear by the end of the third post-vaccinal day. Simultaneous injection of pentavaccine and Hepatitis B vaccine and pneumococcal conjugate vaccine in children with a history of premature infancy, showed no influence during the post-vaccinal period. The reactogenicity of pentavaccine increased along with the vaccination ratio during the primary series of vaccinations.https://vsp.spr-journal.ru/jour/article/view/704premature infantsvaccinationreactogenicitypentavaccinepertussisdiphtheriatetanuspoliomyelitishaemophilus influenzae type b |
| spellingShingle | D. А. Novikova L. S. Namazova-Baranova А. G. Gayvoronskaya М. I. Broeva М. V. Fedoseenko Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment Вопросы современной педиатрии premature infants vaccination reactogenicity pentavaccine pertussis diphtheria tetanus poliomyelitis haemophilus influenzae type b |
| title | Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment |
| title_full | Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment |
| title_fullStr | Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment |
| title_full_unstemmed | Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment |
| title_short | Safety Analysis for Pentavaccine Used in Premature Infants: Family Vaccination Centre’s Experiment |
| title_sort | safety analysis for pentavaccine used in premature infants family vaccination centre s experiment |
| topic | premature infants vaccination reactogenicity pentavaccine pertussis diphtheria tetanus poliomyelitis haemophilus influenzae type b |
| url | https://vsp.spr-journal.ru/jour/article/view/704 |
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