Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery
Ultrasound stimulated drug delivery is attractive for controlled dose and localised delivery to reduce excess loss of drug and side effects, which for antibiotics is pertinent to the fight against antimicrobial resistance. Low frequency ultrasound is commonly used in dental clinical practice for bac...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000951 |
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| author | Grace Ball Jack Stevenson Faraz Amini Boroujeni Ben Jacobson Sarah A. Kuehne Margaret Lucas Anthony Damien Walmsley Paul Prentice Zoe Pikramenou |
| author_facet | Grace Ball Jack Stevenson Faraz Amini Boroujeni Ben Jacobson Sarah A. Kuehne Margaret Lucas Anthony Damien Walmsley Paul Prentice Zoe Pikramenou |
| author_sort | Grace Ball |
| collection | DOAJ |
| description | Ultrasound stimulated drug delivery is attractive for controlled dose and localised delivery to reduce excess loss of drug and side effects, which for antibiotics is pertinent to the fight against antimicrobial resistance. Low frequency ultrasound is commonly used in dental clinical practice for bacterial biofilm removal and is an attractive versatile stimulus for drug release. Here we introduce nonporous (amorphous) silica nanoparticles as a biocompatible, encapsulant for triggered drug release by low frequency ultrasound. A 20 kHz ultrasonic sonotrode is used in to evaluate the release of the antibiotic ciprofloxacin, CPX, from non-porous particles, CPX ⊂ SiO2. Laser doppler vibrometry (LDV) was employed to characterise the ultrasonic vibration displacement of the sonotrode. Drug release from CPX ⊂ SiO2 was monitored for increasing the tip displacement. Clinically relevant quantities of CPX release (5.7 mg/L) occurred at 40 μm tip displacement in our studies. A strong correlation was observed between cavitation features in the acoustic spectra and drug release from CPX ⊂ SiO2. Silica nanoparticles with and without encapsulated CPX, CPX ⊂ SiO2 and SiO2, respectively, were found to promote cavitation at lower amplitudes confirmed by high-speed imaging, in contrast to mesoporous particles with and without adsorbed CPX, CPX@m-SiO2 and m-SiO2. Spectra of the emissions collected via an acoustic cavitation detector supported these results. Our studies demonstrate a novel platform for drug delivery employing low frequency ultrasound for synergistic enhancement of cavitation effects and triggered drug release. |
| format | Article |
| id | doaj-art-4f2585e214b44448b58c7dc02767e7aa |
| institution | OA Journals |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-4f2585e214b44448b58c7dc02767e7aa2025-08-20T02:16:29ZengElsevierUltrasonics Sonochemistry1350-41772025-05-0111610731610.1016/j.ultsonch.2025.107316Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic deliveryGrace Ball0Jack Stevenson1Faraz Amini Boroujeni2Ben Jacobson3Sarah A. Kuehne4Margaret Lucas5Anthony Damien Walmsley6Paul Prentice7Zoe Pikramenou8School of Chemistry, University of Birmingham, Edgbaston B15 2TT, UKCentre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UKCentre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UKCentre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UKSchool of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UKCentre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UKSchool of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UKCentre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UKSchool of Chemistry, University of Birmingham, Edgbaston B15 2TT, UK; Corresponding author.Ultrasound stimulated drug delivery is attractive for controlled dose and localised delivery to reduce excess loss of drug and side effects, which for antibiotics is pertinent to the fight against antimicrobial resistance. Low frequency ultrasound is commonly used in dental clinical practice for bacterial biofilm removal and is an attractive versatile stimulus for drug release. Here we introduce nonporous (amorphous) silica nanoparticles as a biocompatible, encapsulant for triggered drug release by low frequency ultrasound. A 20 kHz ultrasonic sonotrode is used in to evaluate the release of the antibiotic ciprofloxacin, CPX, from non-porous particles, CPX ⊂ SiO2. Laser doppler vibrometry (LDV) was employed to characterise the ultrasonic vibration displacement of the sonotrode. Drug release from CPX ⊂ SiO2 was monitored for increasing the tip displacement. Clinically relevant quantities of CPX release (5.7 mg/L) occurred at 40 μm tip displacement in our studies. A strong correlation was observed between cavitation features in the acoustic spectra and drug release from CPX ⊂ SiO2. Silica nanoparticles with and without encapsulated CPX, CPX ⊂ SiO2 and SiO2, respectively, were found to promote cavitation at lower amplitudes confirmed by high-speed imaging, in contrast to mesoporous particles with and without adsorbed CPX, CPX@m-SiO2 and m-SiO2. Spectra of the emissions collected via an acoustic cavitation detector supported these results. Our studies demonstrate a novel platform for drug delivery employing low frequency ultrasound for synergistic enhancement of cavitation effects and triggered drug release.http://www.sciencedirect.com/science/article/pii/S1350417725000951UltrasoundCavitation responsiveSilica nanoparticlesControlled drug release |
| spellingShingle | Grace Ball Jack Stevenson Faraz Amini Boroujeni Ben Jacobson Sarah A. Kuehne Margaret Lucas Anthony Damien Walmsley Paul Prentice Zoe Pikramenou Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery Ultrasonics Sonochemistry Ultrasound Cavitation responsive Silica nanoparticles Controlled drug release |
| title | Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| title_full | Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| title_fullStr | Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| title_full_unstemmed | Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| title_short | Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| title_sort | non porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery |
| topic | Ultrasound Cavitation responsive Silica nanoparticles Controlled drug release |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000951 |
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