The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study
ABSTRACT Background and Aims Allergic rhinitis and asthma are two common respiratory diseases with allergic etiology in the world's population. Eosinophils and serum IgE levels have been known as inflammatory allergy markers for many years. This study aimed to evaluate the correlation of nasal...
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Wiley
2024-11-01
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| Online Access: | https://doi.org/10.1002/hsr2.70191 |
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| author | Mehdi Torabizadeh Mojtaba Aghaei Najmaldin Saki Mohammad A. Vahid Saeid Bitaraf Bita Bandar |
| author_facet | Mehdi Torabizadeh Mojtaba Aghaei Najmaldin Saki Mohammad A. Vahid Saeid Bitaraf Bita Bandar |
| author_sort | Mehdi Torabizadeh |
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| description | ABSTRACT Background and Aims Allergic rhinitis and asthma are two common respiratory diseases with allergic etiology in the world's population. Eosinophils and serum IgE levels have been known as inflammatory allergy markers for many years. This study aimed to evaluate the correlation of nasal and blood eosinophils with serum IgE levels in allergic rhinitis and asthma patients. Methods This prospective study was done on patients (n = 78) diagnosed with asthma (n = 20), allergic rhinitis (n = 49), and chronic rhinosinusitis with nasal polyposis (CRSwNP) (n = 9) at our hospital in Ahvaz City, Iran. The age of participants in our study ranged from 3 to 73 years, and all of them were subjected to a complete blood count (CBC) test, nasal smear, and determination of serum IgE levels after their consent. Results There was no correlation between serum IgE level and nasal eosinophil count (p = 0.728) or between serum IgE level and blood eosinophil count (p = 0.657); however, a positive correlation was detected between blood and nasal eosinophil levels (p = 0.003). Conclusion There is no significant relationship between serum IgE level and eosinophil count in the blood and nasal secretions. Serum IgE level and blood or nasal eosinophil count are both useful biomarkers for monitoring allergic rhinitis and asthma individually, but no diagnostic conclusion can be drawn from their correlation. |
| format | Article |
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| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-4f235da10ea14f7bb0899fbc423bda622025-08-20T02:05:31ZengWileyHealth Science Reports2398-88352024-11-01711n/an/a10.1002/hsr2.70191The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control StudyMehdi Torabizadeh0Mojtaba Aghaei1Najmaldin Saki2Mohammad A. Vahid3Saeid Bitaraf4Bita Bandar5Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz IranThalassemia & Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz IranThalassemia & Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz IranThalassemia & Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz IranDepartment of Community Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz IranThalassemia & Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz IranABSTRACT Background and Aims Allergic rhinitis and asthma are two common respiratory diseases with allergic etiology in the world's population. Eosinophils and serum IgE levels have been known as inflammatory allergy markers for many years. This study aimed to evaluate the correlation of nasal and blood eosinophils with serum IgE levels in allergic rhinitis and asthma patients. Methods This prospective study was done on patients (n = 78) diagnosed with asthma (n = 20), allergic rhinitis (n = 49), and chronic rhinosinusitis with nasal polyposis (CRSwNP) (n = 9) at our hospital in Ahvaz City, Iran. The age of participants in our study ranged from 3 to 73 years, and all of them were subjected to a complete blood count (CBC) test, nasal smear, and determination of serum IgE levels after their consent. Results There was no correlation between serum IgE level and nasal eosinophil count (p = 0.728) or between serum IgE level and blood eosinophil count (p = 0.657); however, a positive correlation was detected between blood and nasal eosinophil levels (p = 0.003). Conclusion There is no significant relationship between serum IgE level and eosinophil count in the blood and nasal secretions. Serum IgE level and blood or nasal eosinophil count are both useful biomarkers for monitoring allergic rhinitis and asthma individually, but no diagnostic conclusion can be drawn from their correlation.https://doi.org/10.1002/hsr2.70191allergic rhinitisasthmaIgEnasal eosinophils |
| spellingShingle | Mehdi Torabizadeh Mojtaba Aghaei Najmaldin Saki Mohammad A. Vahid Saeid Bitaraf Bita Bandar The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study Health Science Reports allergic rhinitis asthma IgE nasal eosinophils |
| title | The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study |
| title_full | The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study |
| title_fullStr | The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study |
| title_full_unstemmed | The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study |
| title_short | The Association of Nasal and Blood Eosinophils with Serum IgE Level in Allergic Rhinitis and Asthma: A Case‐Control Study |
| title_sort | association of nasal and blood eosinophils with serum ige level in allergic rhinitis and asthma a case control study |
| topic | allergic rhinitis asthma IgE nasal eosinophils |
| url | https://doi.org/10.1002/hsr2.70191 |
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