A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages

A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages

Abstract African swine fever (ASF), caused by African swine fever virus (ASFV), has resulted in significant economic impacts on the global swine industry. Currently, there is no safe and effective commercial vaccine available for ASFV. Thus, the development of effective and readily available therape...

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Bibliographic Details
Main Authors: Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Veterinary Research
Subjects:
African swine fever
African swine fever virus
dual-reporter virus
high-throughput screening
phenazine-1-carboxylic acid
Online Access:https://doi.org/10.1186/s13567-025-01467-2
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