Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance
Vesiculovirus carajas (CARV) is a pathogen with neuroinvasive potential, yet its impact on neuroinflammation and sickness behavior remains poorly understood. In this study, we investigated the neuropathological and immunological responses to CARV encephalitis in adult BALB/c mice. Mice were intranas...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1499658/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850078497767161856 |
|---|---|
| author | Maria Sueli Barbosa Cavalcante Maria Sueli Barbosa Cavalcante Diego Siqueira Santos Lidineuza Machado Araújo Priscilla Lieuthier Freitas Carlos Augusto Moreira Silva Karina Glazianne Barbosa Carvalho Marialva Tereza Ferreira Araújo Eliana Viera Pinto da Silva Ana Paula Drummond Rodrigues de Farias Daniel Guerreiro Diniz Cristovam Wanderley Picanço Diniz José Antonio Picanço Diniz |
| author_facet | Maria Sueli Barbosa Cavalcante Maria Sueli Barbosa Cavalcante Diego Siqueira Santos Lidineuza Machado Araújo Priscilla Lieuthier Freitas Carlos Augusto Moreira Silva Karina Glazianne Barbosa Carvalho Marialva Tereza Ferreira Araújo Eliana Viera Pinto da Silva Ana Paula Drummond Rodrigues de Farias Daniel Guerreiro Diniz Cristovam Wanderley Picanço Diniz José Antonio Picanço Diniz |
| author_sort | Maria Sueli Barbosa Cavalcante |
| collection | DOAJ |
| description | Vesiculovirus carajas (CARV) is a pathogen with neuroinvasive potential, yet its impact on neuroinflammation and sickness behavior remains poorly understood. In this study, we investigated the neuropathological and immunological responses to CARV encephalitis in adult BALB/c mice. Mice were intranasally inoculated with either infected or uninfected brain homogenates, and clinical, histopathological, and cytokine profiles were analyzed. CARV antigens were primarily detected in necrotic neurons, with prominent microglial activation near the ventricles and blood vessels. By day 10 post-infection, infected mice exhibited significantly elevated levels of MCP-1, IFN-γ, IL-12 p70, TNF-α, IL-6, and IL-10 in the brain, indicating a strong inflammatory response. These findings highlight the inflammatory modulation associated with CARV infection and suggest a hematogenous route of neuroinvasion, distinguishing CARV from other vesiculovirus species. This study provides new insights into the pathogenesis of CARV encephalitis and its potential impact on neuroimmune dynamics. |
| format | Article |
| id | doaj-art-4f23465cb4c541128db2ab86a33db45b |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-4f23465cb4c541128db2ab86a33db45b2025-08-20T02:45:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.14996581499658Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistanceMaria Sueli Barbosa Cavalcante0Maria Sueli Barbosa Cavalcante1Diego Siqueira Santos2Lidineuza Machado Araújo3Priscilla Lieuthier Freitas4Carlos Augusto Moreira Silva5Karina Glazianne Barbosa Carvalho6Marialva Tereza Ferreira Araújo7Eliana Viera Pinto da Silva8Ana Paula Drummond Rodrigues de Farias9Daniel Guerreiro Diniz10Cristovam Wanderley Picanço Diniz11José Antonio Picanço Diniz12Programa de Pós-Graduação em Neurociências e Biologia Celular, Universidade Federal do Pará, Belém, Pará, BrazilLaboratório de Análises Clínicas do Hospital Universitário João de Barros Barreto, Empresa Brasileira de Serviços Hospitalares, Belém, Pará, BrazilLaboratório de Análises Clínicas do Hospital Universitário João de Barros Barreto, Empresa Brasileira de Serviços Hospitalares, Belém, Pará, BrazilLaboratório de Análises Clínicas do Hospital Universitário João de Barros Barreto, Empresa Brasileira de Serviços Hospitalares, Belém, Pará, BrazilLaboratório de Análises Clínicas do Hospital Universitário João de Barros Barreto, Empresa Brasileira de Serviços Hospitalares, Belém, Pará, BrazilLaboratório de Anatomopatologia, Instituto de Patologia Cirúrgica e Molecular, Belém, Pará, BrazilLaboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, BrazilLaboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, BrazilSeção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Pará, BrazilLaboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, BrazilLaboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, BrazilLaboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, BrazilLaboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Belém, Pará, BrazilVesiculovirus carajas (CARV) is a pathogen with neuroinvasive potential, yet its impact on neuroinflammation and sickness behavior remains poorly understood. In this study, we investigated the neuropathological and immunological responses to CARV encephalitis in adult BALB/c mice. Mice were intranasally inoculated with either infected or uninfected brain homogenates, and clinical, histopathological, and cytokine profiles were analyzed. CARV antigens were primarily detected in necrotic neurons, with prominent microglial activation near the ventricles and blood vessels. By day 10 post-infection, infected mice exhibited significantly elevated levels of MCP-1, IFN-γ, IL-12 p70, TNF-α, IL-6, and IL-10 in the brain, indicating a strong inflammatory response. These findings highlight the inflammatory modulation associated with CARV infection and suggest a hematogenous route of neuroinvasion, distinguishing CARV from other vesiculovirus species. This study provides new insights into the pathogenesis of CARV encephalitis and its potential impact on neuroimmune dynamics.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1499658/fullVesiculovirus Carajasencephalitishost inflammatory responsecytokinesencephabilitis |
| spellingShingle | Maria Sueli Barbosa Cavalcante Maria Sueli Barbosa Cavalcante Diego Siqueira Santos Lidineuza Machado Araújo Priscilla Lieuthier Freitas Carlos Augusto Moreira Silva Karina Glazianne Barbosa Carvalho Marialva Tereza Ferreira Araújo Eliana Viera Pinto da Silva Ana Paula Drummond Rodrigues de Farias Daniel Guerreiro Diniz Cristovam Wanderley Picanço Diniz José Antonio Picanço Diniz Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance Frontiers in Cellular and Infection Microbiology Vesiculovirus Carajas encephalitis host inflammatory response cytokines encephabilitis |
| title | Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance |
| title_full | Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance |
| title_fullStr | Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance |
| title_full_unstemmed | Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance |
| title_short | Inflammatory and neuropathological responses to Vesiculovirus carajas encephalitis in adult mice: variability, tolerance and resistance |
| title_sort | inflammatory and neuropathological responses to vesiculovirus carajas encephalitis in adult mice variability tolerance and resistance |
| topic | Vesiculovirus Carajas encephalitis host inflammatory response cytokines encephabilitis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1499658/full |
| work_keys_str_mv | AT mariasuelibarbosacavalcante inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT mariasuelibarbosacavalcante inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT diegosiqueirasantos inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT lidineuzamachadoaraujo inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT priscillalieuthierfreitas inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT carlosaugustomoreirasilva inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT karinaglaziannebarbosacarvalho inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT marialvaterezaferreiraaraujo inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT elianavierapintodasilva inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT anapauladrummondrodriguesdefarias inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT danielguerreirodiniz inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT cristovamwanderleypicancodiniz inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance AT joseantoniopicancodiniz inflammatoryandneuropathologicalresponsestovesiculoviruscarajasencephalitisinadultmicevariabilitytoleranceandresistance |