Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats
Objective: This research examined the effects of extracts (alkaloid and phenolic) from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin. Type 2 diabetes was established in the rats by injecting 35 mg/kg of streptozoto...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | World Journal of Traditional Chinese Medicine |
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| Online Access: | https://journals.lww.com/10.4103/wjtcm.wjtcm_86_24 |
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| author | Emmanuel Saviour Saheed Mutiat A. Abdulkareem Fehintoluwa Celestina Adeleke |
| author_facet | Emmanuel Saviour Saheed Mutiat A. Abdulkareem Fehintoluwa Celestina Adeleke |
| author_sort | Emmanuel Saviour Saheed |
| collection | DOAJ |
| description | Objective:
This research examined the effects of extracts (alkaloid and phenolic) from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin. Type 2 diabetes was established in the rats by injecting 35 mg/kg of streptozotocin intraperitoneally.
Materials and Methods:
Forty-three experimental rats were randomly categorized into seven groups of six rats each, with Group 1 as control group, which comprised seven rats. The remaining groups were as follows: group 2 (untreated diabetic rats), Group 3 (metformin-treated diabetic rats), Group 4 (phenolic extract-treated diabetic rats), Group 5 (alkaloids extract-treated diabetic rats), Group 6 (high-dose phenolic extract-treated diabetic rats), and Group 7 (high-dose alkaloids extract-treated diabetic rats).
Results:
The activity levels of various biochemical factors such as catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione, and malondialdehyde were assessed to determine antioxidant status.
Conclusions:
The findings of this study demonstrated that the phenolic and alkaloid extracts from S. occidentalis possess antioxidant properties and show promise in the management of type 2 diabetes. |
| format | Article |
| id | doaj-art-4f16a337629a4379a97c8b3241a11064 |
| institution | DOAJ |
| issn | 2311-8571 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj-art-4f16a337629a4379a97c8b3241a110642025-08-20T02:43:28ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712025-04-0111221922410.4103/wjtcm.wjtcm_86_24Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar RatsEmmanuel Saviour SaheedMutiat A. AbdulkareemFehintoluwa Celestina AdelekeObjective: This research examined the effects of extracts (alkaloid and phenolic) from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin. Type 2 diabetes was established in the rats by injecting 35 mg/kg of streptozotocin intraperitoneally. Materials and Methods: Forty-three experimental rats were randomly categorized into seven groups of six rats each, with Group 1 as control group, which comprised seven rats. The remaining groups were as follows: group 2 (untreated diabetic rats), Group 3 (metformin-treated diabetic rats), Group 4 (phenolic extract-treated diabetic rats), Group 5 (alkaloids extract-treated diabetic rats), Group 6 (high-dose phenolic extract-treated diabetic rats), and Group 7 (high-dose alkaloids extract-treated diabetic rats). Results: The activity levels of various biochemical factors such as catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione, and malondialdehyde were assessed to determine antioxidant status. Conclusions: The findings of this study demonstrated that the phenolic and alkaloid extracts from S. occidentalis possess antioxidant properties and show promise in the management of type 2 diabetes.https://journals.lww.com/10.4103/wjtcm.wjtcm_86_24alkaloiddiabetesphenolicssenna occidentalis extractstreptozotocin |
| spellingShingle | Emmanuel Saviour Saheed Mutiat A. Abdulkareem Fehintoluwa Celestina Adeleke Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats World Journal of Traditional Chinese Medicine alkaloid diabetes phenolics senna occidentalis extract streptozotocin |
| title | Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats |
| title_full | Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats |
| title_fullStr | Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats |
| title_full_unstemmed | Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats |
| title_short | Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats |
| title_sort | effect of phenolic and alkaloid extract of senna occidentalis leaf on the oxidative status of the heart in high fat diet streptozotocin induced type 2 diabetic wistar rats |
| topic | alkaloid diabetes phenolics senna occidentalis extract streptozotocin |
| url | https://journals.lww.com/10.4103/wjtcm.wjtcm_86_24 |
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