Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review
Hyperpolarized (HP) magnetic resonance imaging (MRI) is a groundbreaking imaging platform advancing from research to clinical practice, offering new possibilities for real-time, non-invasive metabolic imaging. This review explores the latest advancements, challenges, and future directions of HP MRI,...
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Elsevier
2025-06-01
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| author | Ching-Yi Hsieh Ying-Chieh Lai Kuan-Ying Lu Gigin Lin |
| author_facet | Ching-Yi Hsieh Ying-Chieh Lai Kuan-Ying Lu Gigin Lin |
| author_sort | Ching-Yi Hsieh |
| collection | DOAJ |
| description | Hyperpolarized (HP) magnetic resonance imaging (MRI) is a groundbreaking imaging platform advancing from research to clinical practice, offering new possibilities for real-time, non-invasive metabolic imaging. This review explores the latest advancements, challenges, and future directions of HP MRI, emphasizing its transformative impact on both translational research and clinical applications. By employing techniques such as dissolution Dynamic Nuclear Polarization (dDNP), Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and Spin-Exchange Optical Pumping (SEOP), HP MRI achieves enhanced nuclear spin polarization, enabling in vivo visualization of metabolic pathways with exceptional sensitivity. Current challenges, such as limited imaging windows, complex pre-scan protocols, and data processing difficulties, are addressed through innovative solutions like advanced pulse sequences, bolus tracking, and kinetic modeling. We highlight the evolution of HP MRI technology, focusing on its potential to revolutionize disease diagnosis and monitoring by revealing metabolic processes beyond the reach of conventional MRI and positron emission tomography (PET). Key advancements include the development of novel tracers like [2–13C]pyruvate and [1–13C]-alpha-ketoglutarate and improved data analysis techniques, broadening the scope of clinical metabolic imaging. Future prospects emphasize integrating artificial intelligence, standardizing imaging protocols, and developing new hyperpolarized agents to enhance reproducibility and expand clinical capabilities particularly in oncology, cardiology, and neurology. Ultimately, we envisioned HP MRI as a standardized modality for dynamic metabolic imaging in clinical practice. |
| format | Article |
| id | doaj-art-4f15ba68751e4a9facfd8d0d831b3e44 |
| institution | DOAJ |
| issn | 2319-4170 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| spelling | doaj-art-4f15ba68751e4a9facfd8d0d831b3e442025-08-20T02:44:50ZengElsevierBiomedical Journal2319-41702025-06-0148310080210.1016/j.bj.2024.100802Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive reviewChing-Yi Hsieh0Ying-Chieh Lai1Kuan-Ying Lu2Gigin Lin3Research Center for Radiation Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanResearch Center for Radiation Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Corresponding author. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St., Guishan, Taoyuan 33382, Taiwan.Hyperpolarized (HP) magnetic resonance imaging (MRI) is a groundbreaking imaging platform advancing from research to clinical practice, offering new possibilities for real-time, non-invasive metabolic imaging. This review explores the latest advancements, challenges, and future directions of HP MRI, emphasizing its transformative impact on both translational research and clinical applications. By employing techniques such as dissolution Dynamic Nuclear Polarization (dDNP), Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and Spin-Exchange Optical Pumping (SEOP), HP MRI achieves enhanced nuclear spin polarization, enabling in vivo visualization of metabolic pathways with exceptional sensitivity. Current challenges, such as limited imaging windows, complex pre-scan protocols, and data processing difficulties, are addressed through innovative solutions like advanced pulse sequences, bolus tracking, and kinetic modeling. We highlight the evolution of HP MRI technology, focusing on its potential to revolutionize disease diagnosis and monitoring by revealing metabolic processes beyond the reach of conventional MRI and positron emission tomography (PET). Key advancements include the development of novel tracers like [2–13C]pyruvate and [1–13C]-alpha-ketoglutarate and improved data analysis techniques, broadening the scope of clinical metabolic imaging. Future prospects emphasize integrating artificial intelligence, standardizing imaging protocols, and developing new hyperpolarized agents to enhance reproducibility and expand clinical capabilities particularly in oncology, cardiology, and neurology. Ultimately, we envisioned HP MRI as a standardized modality for dynamic metabolic imaging in clinical practice.http://www.sciencedirect.com/science/article/pii/S2319417024001057Carbon-13Dynamic nuclear polarizationHyperpolarizationMagnetic resonance imagingMagnetic resonance spectroscopy |
| spellingShingle | Ching-Yi Hsieh Ying-Chieh Lai Kuan-Ying Lu Gigin Lin Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review Biomedical Journal Carbon-13 Dynamic nuclear polarization Hyperpolarization Magnetic resonance imaging Magnetic resonance spectroscopy |
| title | Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review |
| title_full | Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review |
| title_fullStr | Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review |
| title_full_unstemmed | Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review |
| title_short | Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review |
| title_sort | advancements challenges and future prospects in clinical hyperpolarized magnetic resonance imaging a comprehensive review |
| topic | Carbon-13 Dynamic nuclear polarization Hyperpolarization Magnetic resonance imaging Magnetic resonance spectroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S2319417024001057 |
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