Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells

Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells

Abstract Amyloid β42 (Aβ42) plays a decisive role in the pathology of Alzheimer’s disease. The Aβ42 peptide can aggregate into various supramolecular structures, with oligomers being the most toxic form. However, different Aβ species that cause different effects have been described. Many cell death...

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Bibliographic Details
Main Authors: Alp Yigit Özdemir, Kateřina Hofbauerová, Vladimír Kopecký, Jiří Novotný, Vladimír Rudajev
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
Amyloid β42
Alzheimer´s disease
Cell death
Apoptosis
Necroptosis
Reactive oxygen species
Online Access:https://doi.org/10.1186/s11658-024-00657-8
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