Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice
Chinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular dev...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2276770 |
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| author | Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu |
| author_facet | Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu |
| author_sort | Yumin Chen |
| collection | DOAJ |
| description | Chinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical carbon nanostructures ranging from 0.97 to 2.3 nm in diameter, with fluorescent properties and a surface rich in functional groups. We further investigated the impact of ZR-CDs on oestradiol and FSH in serum, growth, and the development of ovarian and uterine using normal female mice and exogenous oestradiol intervention model. It was observed that ZR-CDs accelerated oestrogen metabolism and attenuated oestradiol-induced endometrial hyperplasia. Simultaneously, ZR-CDs triggered an increase in FSH, even in the presence of high-serum oestradiol that inhibits FSH secretion. Our findings suggest that ZR-CDs could be a potential therapeutic treatment for anovulatory menstruation. |
| format | Article |
| id | doaj-art-4f0b9b0274784f5da89c9944c80fec25 |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-4f0b9b0274784f5da89c9944c80fec252024-12-06T10:48:00ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2024-12-01521122210.1080/21691401.2023.2276770Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female miceYumin Chen0Xue Bai1Ying Zhang2Yafang Zhao3Huagen Ma4Yunbo Yang5Meijun Wang6Yinghui Guo7Xiaopeng Li8Tong Wu9Yue Zhang10Hui Kong11Yan Zhao12Huaihua Qu13School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, ChinaChinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical carbon nanostructures ranging from 0.97 to 2.3 nm in diameter, with fluorescent properties and a surface rich in functional groups. We further investigated the impact of ZR-CDs on oestradiol and FSH in serum, growth, and the development of ovarian and uterine using normal female mice and exogenous oestradiol intervention model. It was observed that ZR-CDs accelerated oestrogen metabolism and attenuated oestradiol-induced endometrial hyperplasia. Simultaneously, ZR-CDs triggered an increase in FSH, even in the presence of high-serum oestradiol that inhibits FSH secretion. Our findings suggest that ZR-CDs could be a potential therapeutic treatment for anovulatory menstruation.https://www.tandfonline.com/doi/10.1080/21691401.2023.2276770Zingiberis rhizoma-based carbon dotsoestradiolfollicle-stimulating hormoneovary |
| spellingShingle | Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice Artificial Cells, Nanomedicine, and Biotechnology Zingiberis rhizoma-based carbon dots oestradiol follicle-stimulating hormone ovary |
| title | Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice |
| title_full | Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice |
| title_fullStr | Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice |
| title_full_unstemmed | Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice |
| title_short | Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice |
| title_sort | zingiberis rhizoma based carbon dots alter serum oestradiol and follicle stimulating hormone levels in female mice |
| topic | Zingiberis rhizoma-based carbon dots oestradiol follicle-stimulating hormone ovary |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2276770 |
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