Association of NAT2 promoter hypermethylation with susceptibility to hepatotoxicity due to antituberculosis drugs and biomarker potential

Association of NAT2 promoter hypermethylation with susceptibility to hepatotoxicity due to antituberculosis drugs and biomarker potential

Abstract This study aimed to determine whether promoter methylation of N-acetyltransferase 2 (NAT2), a metabolic enzyme responsible for drug metabolism and detoxification, was correlated with clinical parameters indicating anti-tuberculosis drug-induced liver injury (ATDILI) in tuberculosis patients...

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Main Authors: Jiraphun Jittikoon, Wacharapol Saengsiwaritt, Noppadol Chanhom, Usa Chaikledkaew, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Wanvisa Udomsinprasert
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
N-Acetyltransferase 2 (NAT2)
Promoter methylation
Anti-tuberculosis drug-induced liver injury
Tuberculosis
Biomarker
Online Access:https://doi.org/10.1038/s41598-025-95050-6
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