Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol
Introduction The COVID-19 pandemic, driven by the SARS-CoV-2 virus, has had a significant global impact, with over 775 million cases reported and more than 7 million deaths as of July 2024. In Chile, approximately 5.4 million people have been infected, with a substantial proportion experiencing pers...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-05-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/5/e093844.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239911002636288 |
|---|---|
| author | Vivienne C Bachelet Karena Espinoza Lindybeth Sarmiento Varón Hermy Alvarez Leyla Carolina Huirimilla Casanova Maria Paz Díaz Mora Luis Alfredo Muñoz Cuevas Jorge Gonzalez-Puelma Lidia Amarales Jonathan Lühr Henriquez Felipe Retamal-Matus Roberto Uribe-Paredes Cristian Andrés Núñez-Espinosa Claudia Estrada-Goic Mercedes N López Nitsche Marcelo A Navarrete |
| author_facet | Vivienne C Bachelet Karena Espinoza Lindybeth Sarmiento Varón Hermy Alvarez Leyla Carolina Huirimilla Casanova Maria Paz Díaz Mora Luis Alfredo Muñoz Cuevas Jorge Gonzalez-Puelma Lidia Amarales Jonathan Lühr Henriquez Felipe Retamal-Matus Roberto Uribe-Paredes Cristian Andrés Núñez-Espinosa Claudia Estrada-Goic Mercedes N López Nitsche Marcelo A Navarrete |
| author_sort | Vivienne C Bachelet |
| collection | DOAJ |
| description | Introduction The COVID-19 pandemic, driven by the SARS-CoV-2 virus, has had a significant global impact, with over 775 million cases reported and more than 7 million deaths as of July 2024. In Chile, approximately 5.4 million people have been infected, with a substantial proportion experiencing persistent symptoms known as post-COVID-19 syndrome. This study aims to estimate the prevalence of post-COVID-19 syndrome in Punta Arenas, Chile, and to explore the associated symptoms, mainly focusing on psychological, physical and molecular impacts on the affected population.Methods and analysis This cross-sectional study will use stratified random sampling to select a representative sample of 282 adults from Punta Arenas. Participants eligible for the study are those who had tested positive for SARS-CoV-2 by reverse transcription-quantitative PCR between July 2022 and July 2023. Data collection will include comprehensive clinical assessments, psychological evaluations and laboratory analyses of inflammatory biomarkers. Standardised instruments will be used to ensure consistency and reliability in measuring persistent symptoms. Statistical analyses will include descriptive statistics, regression models and subgroup analyses to identify risk factors and the prevalence of post-COVID-19 syndrome.Ethics and dissemination The Human Research Ethics Committee of the Clinical Hospital of the University of Chile approved the study protocol (Memorandum No 007/2023). We will present the results in peer-reviewed publications and national and international professional and academic meetings.Trial registration number NCT05855382. |
| format | Article |
| id | doaj-art-4f06e40f8a4a4ee6aa9a2fc12b52909b |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-4f06e40f8a4a4ee6aa9a2fc12b52909b2025-08-20T02:01:00ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2024-093844Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocolVivienne C Bachelet0Karena Espinoza1Lindybeth Sarmiento Varón2Hermy Alvarez3Leyla Carolina Huirimilla Casanova4Maria Paz Díaz Mora5Luis Alfredo Muñoz Cuevas6Jorge Gonzalez-Puelma7Lidia Amarales8Jonathan Lühr Henriquez9Felipe Retamal-Matus10Roberto Uribe-Paredes11Cristian Andrés Núñez-Espinosa12Claudia Estrada-Goic13Mercedes N López Nitsche14Marcelo A Navarrete15MedwaveFacultad de Medicina, Center for Genetics and Genomics, Clinica Alemana Universidad del Desarrollo, Santiago, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileEscuela de Medicina, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileDepartamento de Ingeniería en Computación, Facultad de Ingeniería, Universidad de Magallanes, Punta Arenas, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileDepartamento de Psicología, Universidad de Magallanes, Punta Arenas, ChileInstituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, ChileCentro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, ChileIntroduction The COVID-19 pandemic, driven by the SARS-CoV-2 virus, has had a significant global impact, with over 775 million cases reported and more than 7 million deaths as of July 2024. In Chile, approximately 5.4 million people have been infected, with a substantial proportion experiencing persistent symptoms known as post-COVID-19 syndrome. This study aims to estimate the prevalence of post-COVID-19 syndrome in Punta Arenas, Chile, and to explore the associated symptoms, mainly focusing on psychological, physical and molecular impacts on the affected population.Methods and analysis This cross-sectional study will use stratified random sampling to select a representative sample of 282 adults from Punta Arenas. Participants eligible for the study are those who had tested positive for SARS-CoV-2 by reverse transcription-quantitative PCR between July 2022 and July 2023. Data collection will include comprehensive clinical assessments, psychological evaluations and laboratory analyses of inflammatory biomarkers. Standardised instruments will be used to ensure consistency and reliability in measuring persistent symptoms. Statistical analyses will include descriptive statistics, regression models and subgroup analyses to identify risk factors and the prevalence of post-COVID-19 syndrome.Ethics and dissemination The Human Research Ethics Committee of the Clinical Hospital of the University of Chile approved the study protocol (Memorandum No 007/2023). We will present the results in peer-reviewed publications and national and international professional and academic meetings.Trial registration number NCT05855382.https://bmjopen.bmj.com/content/15/5/e093844.full |
| spellingShingle | Vivienne C Bachelet Karena Espinoza Lindybeth Sarmiento Varón Hermy Alvarez Leyla Carolina Huirimilla Casanova Maria Paz Díaz Mora Luis Alfredo Muñoz Cuevas Jorge Gonzalez-Puelma Lidia Amarales Jonathan Lühr Henriquez Felipe Retamal-Matus Roberto Uribe-Paredes Cristian Andrés Núñez-Espinosa Claudia Estrada-Goic Mercedes N López Nitsche Marcelo A Navarrete Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol BMJ Open |
| title | Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol |
| title_full | Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol |
| title_fullStr | Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol |
| title_full_unstemmed | Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol |
| title_short | Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol |
| title_sort | estimating the prevalence of persistent symptoms after sars cov 2 infection post covid 19 syndrome a regional cross sectional study protocol |
| url | https://bmjopen.bmj.com/content/15/5/e093844.full |
| work_keys_str_mv | AT viviennecbachelet estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT karenaespinoza estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT lindybethsarmientovaron estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT hermyalvarez estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT leylacarolinahuirimillacasanova estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT mariapazdiazmora estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT luisalfredomunozcuevas estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT jorgegonzalezpuelma estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT lidiaamarales estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT jonathanluhrhenriquez estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT feliperetamalmatus estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT robertouribeparedes estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT cristianandresnunezespinosa estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT claudiaestradagoic estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT mercedesnlopeznitsche estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol AT marceloanavarrete estimatingtheprevalenceofpersistentsymptomsaftersarscov2infectionpostcovid19syndromearegionalcrosssectionalstudyprotocol |