Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases
Objective: to reveal the prevalence of infection by various variants of betaherpesvirus 6 А/В types in children with clinical manifestations of acute respiratory disease in case of betaherpesvirus 6 type DNA identification in the blood and to specify the features of diagnostic markers during mono- a...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2022-04-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1312 |
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| author | O. V. Goleva I. V. Babachenko E. V. Sharipova Е. А. Murina Yu. A. Eismont R. S. Kalinin A. B. Chukhlovin Z. А. Osipova A. L. Mukomolova A. V. Krylov O. S. Glotov |
| author_facet | O. V. Goleva I. V. Babachenko E. V. Sharipova Е. А. Murina Yu. A. Eismont R. S. Kalinin A. B. Chukhlovin Z. А. Osipova A. L. Mukomolova A. V. Krylov O. S. Glotov |
| author_sort | O. V. Goleva |
| collection | DOAJ |
| description | Objective: to reveal the prevalence of infection by various variants of betaherpesvirus 6 А/В types in children with clinical manifestations of acute respiratory disease in case of betaherpesvirus 6 type DNA identification in the blood and to specify the features of diagnostic markers during mono- and mixed herpesvirus infection.Materials and methods: there was made the analysis of clinical and laboratory data of 71 patients with the medical history of recurrent respiratory diseases or suspicion about exanthem subitum, hospitalized to Pediatric Research and Clinical Center for Infectious Diseases with the symptoms of acute respiratory disease and betaherpesvirus 6 type DNA identification in the blood. Laboratory investigation included molecular and biological methods of respiratory group and herpesviruses identification, as well as serological methods of antiviral antibodies identification.Results: among the patients hospitalized with clinical manifestations of acute respiratory infection or exanthem subitum and presence of betaherpesvirus 6 DNA in the blood, 24, 0% of the patients had the markers of respiratory viruses in swabs taken from nasopharynx, 21,1% of the cases were diagnosed as viral-bacterial infection in the patients with a complicated course of the disease. 40,8% of the cases were registered as a mixed infection caused by betaherpesvirus 6 and Epstein-Barr virus. In 99% of the cases the patients were infected by human betaherpesvirus 6В; and in 1% of the cases - by human betaherpesvirus 6 А. One patient was characterized by a constant isolation of betaherpesvirus 6 А from his blood and oropharynx scrape in invariable concentration without any dependence on the administered treatment and the disease acuity.Conclusions: betaherpesvirus 6 В was isolated in the blood of the patients in 99% of the cases, and 6 A – in 1% of the cases. The infection caused by Epstein-Barr virus was revealed more often in case of mixed infection by herpesviruses, with the markers of acute period or reactivation. The patient with confirmed betaherpesvirus 6 А had invariable virus load in his blood and oropharynx scrape that is likely to be connected with the virus genome integration in human cell DNA without provoking pathology. |
| format | Article |
| id | doaj-art-4f01a06edbc14a669b87f07e45ee1724 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-4f01a06edbc14a669b87f07e45ee17242025-08-20T02:55:14ZrusJournal InfectologyЖурнал инфектологии2072-67322022-04-01141889510.22625/2072-6732-2022-14-1-88-95973Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseasesO. V. Goleva0I. V. Babachenko1E. V. Sharipova2Е. А. Murina3Yu. A. Eismont4R. S. Kalinin5A. B. Chukhlovin6Z. А. Osipova7A. L. Mukomolova8A. V. Krylov9O. S. Glotov10Pediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious Diseases; The First Saint-Petersburg State Medical University named after academician I.P. PavlovPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesObjective: to reveal the prevalence of infection by various variants of betaherpesvirus 6 А/В types in children with clinical manifestations of acute respiratory disease in case of betaherpesvirus 6 type DNA identification in the blood and to specify the features of diagnostic markers during mono- and mixed herpesvirus infection.Materials and methods: there was made the analysis of clinical and laboratory data of 71 patients with the medical history of recurrent respiratory diseases or suspicion about exanthem subitum, hospitalized to Pediatric Research and Clinical Center for Infectious Diseases with the symptoms of acute respiratory disease and betaherpesvirus 6 type DNA identification in the blood. Laboratory investigation included molecular and biological methods of respiratory group and herpesviruses identification, as well as serological methods of antiviral antibodies identification.Results: among the patients hospitalized with clinical manifestations of acute respiratory infection or exanthem subitum and presence of betaherpesvirus 6 DNA in the blood, 24, 0% of the patients had the markers of respiratory viruses in swabs taken from nasopharynx, 21,1% of the cases were diagnosed as viral-bacterial infection in the patients with a complicated course of the disease. 40,8% of the cases were registered as a mixed infection caused by betaherpesvirus 6 and Epstein-Barr virus. In 99% of the cases the patients were infected by human betaherpesvirus 6В; and in 1% of the cases - by human betaherpesvirus 6 А. One patient was characterized by a constant isolation of betaherpesvirus 6 А from his blood and oropharynx scrape in invariable concentration without any dependence on the administered treatment and the disease acuity.Conclusions: betaherpesvirus 6 В was isolated in the blood of the patients in 99% of the cases, and 6 A – in 1% of the cases. The infection caused by Epstein-Barr virus was revealed more often in case of mixed infection by herpesviruses, with the markers of acute period or reactivation. The patient with confirmed betaherpesvirus 6 А had invariable virus load in his blood and oropharynx scrape that is likely to be connected with the virus genome integration in human cell DNA without provoking pathology.https://journal.niidi.ru/jofin/article/view/1312betaherpesvirus 6 а/вmixed infectiondiagnosticschromosomal integration of betaherpesvirus 6 type |
| spellingShingle | O. V. Goleva I. V. Babachenko E. V. Sharipova Е. А. Murina Yu. A. Eismont R. S. Kalinin A. B. Chukhlovin Z. А. Osipova A. L. Mukomolova A. V. Krylov O. S. Glotov Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases Журнал инфектологии betaherpesvirus 6 а/в mixed infection diagnostics chromosomal integration of betaherpesvirus 6 type |
| title | Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases |
| title_full | Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases |
| title_fullStr | Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases |
| title_full_unstemmed | Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases |
| title_short | Diagnostic markers of betaherpesvirus 6 infection of A and B types in children with respiratory diseases |
| title_sort | diagnostic markers of betaherpesvirus 6 infection of a and b types in children with respiratory diseases |
| topic | betaherpesvirus 6 а/в mixed infection diagnostics chromosomal integration of betaherpesvirus 6 type |
| url | https://journal.niidi.ru/jofin/article/view/1312 |
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