The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq
Background and objectives: Platelets are an important link between inflammation and thrombosis and play a significant role in different stages of atherosclerotic plaque formation. This study aimed to define the correlation between variation in admission platelet parameters and acute coronary syndro...
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Kurdistan Higher Council Of Medical Specialties
2023-06-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/249 |
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| _version_ | 1849698912871383040 |
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| author | Kocher Hassan Abdullah Awaz Ahmed Kamal Shalli Ali Ibrahim Mohammed Sana Dlawar Jalal |
| author_facet | Kocher Hassan Abdullah Awaz Ahmed Kamal Shalli Ali Ibrahim Mohammed Sana Dlawar Jalal |
| author_sort | Kocher Hassan Abdullah |
| collection | DOAJ |
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Background and objectives: Platelets are an important link between inflammation and thrombosis and play a significant role in different stages of atherosclerotic plaque formation. This study aimed to define the correlation between variation in admission platelet parameters and acute coronary syndrome and to investigate the diagnostic accuracy of platelets parameters used.
Methods: The study was performed at Sulaimani Cardiac Care Hospital and Sulaimani Public Health Lab. One hundred cases of diagnosed acute coronary syndrome; ST elevation myocardial infarction, non-ST elevation myocardial infarction, and unstable angina were included and compared with 100 apparently healthy subjects. Participants were enrolled after taking a detailed history and complete blood count to assess the platelets parameters.
Results: A significantly lower admission mean platelets count was found in patients (252x 109/l ± 81.3) than in control (291x109/l ± 67.6). The mean platelet volume, platelet distribution width and plateletcrit of the patients were all significantly higher. Furthermore, a significant correlation was detected between acute coronary syndrome with mean platelet volume and platelet distribution width. The risk of acute coronary syndrome rose up to approximately 9 times among patients with high mean platelet volume. Moreover, mean platelet volume showed a high sensitivity (88%) and specificity (89%) to detect patients with acute coronary syndrome, unlike platelet crit and platelet distribution width that were of lesser sensitivity and specificity.
Conclusions: Admission platelets parameters are readily available laboratory tests, and are of merit in identifying acute coronary syndrome patients.
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| format | Article |
| id | doaj-art-4efd36927e1f4c8a81a6074897ba6699 |
| institution | DOAJ |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-4efd36927e1f4c8a81a6074897ba66992025-08-20T03:18:46ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802023-06-015210.56056/amj.2019.95250The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern IraqKocher Hassan Abdullah0Awaz Ahmed Kamal Shalli1Ali Ibrahim Mohammed2Sana Dlawar Jalal3MBChB, FKBMS Sulaimani General Teaching Hospital, Sulaimani, IraqMBChB, MSC. Department of Pathology, Sulaimani College of Medicine, University of Sulaimani, Sulaimani, IraqMBChB, FIBMS. Department of Pathology, Sulaimani College of Medicine, University of Sulaimani, Sulaimani, IraqMBChB, FRCPath. Department of Pathology, Sulaimani College of Medicine, University of Sulaimani, Sulaimani, Iraq Background and objectives: Platelets are an important link between inflammation and thrombosis and play a significant role in different stages of atherosclerotic plaque formation. This study aimed to define the correlation between variation in admission platelet parameters and acute coronary syndrome and to investigate the diagnostic accuracy of platelets parameters used. Methods: The study was performed at Sulaimani Cardiac Care Hospital and Sulaimani Public Health Lab. One hundred cases of diagnosed acute coronary syndrome; ST elevation myocardial infarction, non-ST elevation myocardial infarction, and unstable angina were included and compared with 100 apparently healthy subjects. Participants were enrolled after taking a detailed history and complete blood count to assess the platelets parameters. Results: A significantly lower admission mean platelets count was found in patients (252x 109/l ± 81.3) than in control (291x109/l ± 67.6). The mean platelet volume, platelet distribution width and plateletcrit of the patients were all significantly higher. Furthermore, a significant correlation was detected between acute coronary syndrome with mean platelet volume and platelet distribution width. The risk of acute coronary syndrome rose up to approximately 9 times among patients with high mean platelet volume. Moreover, mean platelet volume showed a high sensitivity (88%) and specificity (89%) to detect patients with acute coronary syndrome, unlike platelet crit and platelet distribution width that were of lesser sensitivity and specificity. Conclusions: Admission platelets parameters are readily available laboratory tests, and are of merit in identifying acute coronary syndrome patients. https://amj.khcms.edu.krd/index.php/main/article/view/249Acute coronary syndromeMean platelet volumePlateletcrit |
| spellingShingle | Kocher Hassan Abdullah Awaz Ahmed Kamal Shalli Ali Ibrahim Mohammed Sana Dlawar Jalal The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq Advanced Medical Journal Acute coronary syndrome Mean platelet volume Plateletcrit |
| title | The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq |
| title_full | The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq |
| title_fullStr | The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq |
| title_full_unstemmed | The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq |
| title_short | The evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern Iraq |
| title_sort | evaluation of platelets parameters in patients with acute coronary syndrome from single cardiac center in northeastern iraq |
| topic | Acute coronary syndrome Mean platelet volume Plateletcrit |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/249 |
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