Shared subcortical arousal systems across sensory modalities during transient modulation of attention
Subcortical arousal systems are known to play a key role in controlling sustained changes in attention and conscious awareness. Recent studies indicate that these systems have a major influence on short-term dynamic modulation of visual attention, but their role across sensory modalities is not full...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925002277 |
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| author | Aya Khalaf Erick Lopez Jian Li Andreas Horn Brian L. Edlow Hal Blumenfeld |
| author_facet | Aya Khalaf Erick Lopez Jian Li Andreas Horn Brian L. Edlow Hal Blumenfeld |
| author_sort | Aya Khalaf |
| collection | DOAJ |
| description | Subcortical arousal systems are known to play a key role in controlling sustained changes in attention and conscious awareness. Recent studies indicate that these systems have a major influence on short-term dynamic modulation of visual attention, but their role across sensory modalities is not fully understood. In this study, we investigated shared subcortical arousal systems across sensory modalities during transient changes in attention using block and event-related fMRI paradigms. We analyzed massive publicly available fMRI datasets collected while 1561 participants performed visual, auditory, tactile, and taste perception tasks. Our analyses revealed a shared circuit of subcortical arousal systems exhibiting early transient increases in activity in midbrain reticular formation and central thalamus across perceptual modalities, as well as less consistent increases in pons, hypothalamus, basal forebrain, and basal ganglia. Identifying these networks is critical for understanding mechanisms of normal attention and consciousness and may help facilitate subcortical targeting for therapeutic neuromodulation. |
| format | Article |
| id | doaj-art-4efd2b79c44548338d2d6277fe917cff |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-4efd2b79c44548338d2d6277fe917cff2025-08-20T02:15:58ZengElsevierNeuroImage1095-95722025-05-0131212122410.1016/j.neuroimage.2025.121224Shared subcortical arousal systems across sensory modalities during transient modulation of attentionAya Khalaf0Erick Lopez1Jian Li2Andreas Horn3Brian L. Edlow4Hal Blumenfeld5Department of Neurology, Yale University School of Medicine, New Haven, CT, USADepartment of Neurology, Yale University School of Medicine, New Haven, CT, USADepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USADepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Brain Circuit Therapeutics, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Movement Disorders & Neuromodulation Section, Department of Neurology, Charité – Universitätsmedizin, Berlin, GermanyDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USADepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Corresponding author at: Yale Depts. Neurology, Neuroscience, Neurosurgery 333 Cedar Street, New Haven, CT 06520-8018, USASubcortical arousal systems are known to play a key role in controlling sustained changes in attention and conscious awareness. Recent studies indicate that these systems have a major influence on short-term dynamic modulation of visual attention, but their role across sensory modalities is not fully understood. In this study, we investigated shared subcortical arousal systems across sensory modalities during transient changes in attention using block and event-related fMRI paradigms. We analyzed massive publicly available fMRI datasets collected while 1561 participants performed visual, auditory, tactile, and taste perception tasks. Our analyses revealed a shared circuit of subcortical arousal systems exhibiting early transient increases in activity in midbrain reticular formation and central thalamus across perceptual modalities, as well as less consistent increases in pons, hypothalamus, basal forebrain, and basal ganglia. Identifying these networks is critical for understanding mechanisms of normal attention and consciousness and may help facilitate subcortical targeting for therapeutic neuromodulation.http://www.sciencedirect.com/science/article/pii/S1053811925002277Attention modulationArousalConsciousnessSubcortical networksfMRI |
| spellingShingle | Aya Khalaf Erick Lopez Jian Li Andreas Horn Brian L. Edlow Hal Blumenfeld Shared subcortical arousal systems across sensory modalities during transient modulation of attention NeuroImage Attention modulation Arousal Consciousness Subcortical networks fMRI |
| title | Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| title_full | Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| title_fullStr | Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| title_full_unstemmed | Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| title_short | Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| title_sort | shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| topic | Attention modulation Arousal Consciousness Subcortical networks fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925002277 |
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