Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery
<i>Background and Objectives</i>: Colorectal cancer is the third most common type of cancer in men and women. With advancements in technology, minimally invasive treatment options have become increasingly prominent in colorectal cancer surgery. This study aimed to compare the increased i...
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MDPI AG
2024-12-01
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| author | Abdullah Gürhan Duyan Celalettin Vatansev Rahim Kocabaş Melek Yalçın Koç Muhammed Ali Akbulut |
| author_facet | Abdullah Gürhan Duyan Celalettin Vatansev Rahim Kocabaş Melek Yalçın Koç Muhammed Ali Akbulut |
| author_sort | Abdullah Gürhan Duyan |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Colorectal cancer is the third most common type of cancer in men and women. With advancements in technology, minimally invasive treatment options have become increasingly prominent in colorectal cancer surgery. This study aimed to compare the increased intra-abdominal pressure in laparoscopic colon and rectal surgery with open procedures using kidney injury molecule-1 (KIM-1) secreted from renal tubules. <i>Materials and Methods</i>: We enrolled 46 patients diagnosed with colon cancer who underwent laparoscopic and open surgical procedures at our clinic. The patients were prospectively randomized into five groups: 10 laparoscopic right hemicolectomies (Group 1), 8 open right hemicolectomies (Group 2), 8 laparoscopic anterior resections (LARs) (Group 3), 11 open anterior resections (Group 4), and 9 laparoscopic low anterior resections (Group 5). Urine samples were collected from the patients preoperatively, postoperatively at the 4th hour, and postoperatively on the 14th day, and the urine KIM-1 levels and urine creatinine (Cr) values were measured. The urine KIM-1/Cr ratios were subsequently calculated. <i>Results</i>: The urinary KIM-1/Cr levels increased at the 4th postoperative hour after the open and laparoscopic procedures. On postoperative day 14, the urinary KIM-1/Cr levels were lower than those in the preoperative period in all groups, except the LAR group. <i>Conclusions</i>: Our study shown that the average pressure in laparoscopic colon and rectal surgery did not have a long-term impact on kidney injury in comparison to open colon and rectal surgery. |
| format | Article |
| id | doaj-art-4ef755633687475babe45657fa4cffd4 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-4ef755633687475babe45657fa4cffd42025-01-24T13:40:21ZengMDPI AGMedicina1010-660X1648-91442024-12-016114210.3390/medicina61010042Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer SurgeryAbdullah Gürhan Duyan0Celalettin Vatansev1Rahim Kocabaş2Melek Yalçın Koç3Muhammed Ali Akbulut4Konya City Hospital, Konya 42020, TurkeyFaculty of Medicine, Necmettin Erbakan University, Konya 42090, TurkeyFaculty of Medicine, Karamanoğlu Mehmetbey University, Karaman 70100, TurkeyBeyhekim Training and Research Hospital, Konya 42060, TurkeyKonya City Hospital, Konya 42020, Turkey<i>Background and Objectives</i>: Colorectal cancer is the third most common type of cancer in men and women. With advancements in technology, minimally invasive treatment options have become increasingly prominent in colorectal cancer surgery. This study aimed to compare the increased intra-abdominal pressure in laparoscopic colon and rectal surgery with open procedures using kidney injury molecule-1 (KIM-1) secreted from renal tubules. <i>Materials and Methods</i>: We enrolled 46 patients diagnosed with colon cancer who underwent laparoscopic and open surgical procedures at our clinic. The patients were prospectively randomized into five groups: 10 laparoscopic right hemicolectomies (Group 1), 8 open right hemicolectomies (Group 2), 8 laparoscopic anterior resections (LARs) (Group 3), 11 open anterior resections (Group 4), and 9 laparoscopic low anterior resections (Group 5). Urine samples were collected from the patients preoperatively, postoperatively at the 4th hour, and postoperatively on the 14th day, and the urine KIM-1 levels and urine creatinine (Cr) values were measured. The urine KIM-1/Cr ratios were subsequently calculated. <i>Results</i>: The urinary KIM-1/Cr levels increased at the 4th postoperative hour after the open and laparoscopic procedures. On postoperative day 14, the urinary KIM-1/Cr levels were lower than those in the preoperative period in all groups, except the LAR group. <i>Conclusions</i>: Our study shown that the average pressure in laparoscopic colon and rectal surgery did not have a long-term impact on kidney injury in comparison to open colon and rectal surgery.https://www.mdpi.com/1648-9144/61/1/42kidney injury molecule-1laparoscopic colon and rectal surgeryrenal tubular damage |
| spellingShingle | Abdullah Gürhan Duyan Celalettin Vatansev Rahim Kocabaş Melek Yalçın Koç Muhammed Ali Akbulut Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery Medicina kidney injury molecule-1 laparoscopic colon and rectal surgery renal tubular damage |
| title | Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery |
| title_full | Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery |
| title_fullStr | Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery |
| title_full_unstemmed | Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery |
| title_short | Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery |
| title_sort | comparison of renal tubular damage with kidney injury molecule 1 in open and laparoscopic colorectal cancer surgery |
| topic | kidney injury molecule-1 laparoscopic colon and rectal surgery renal tubular damage |
| url | https://www.mdpi.com/1648-9144/61/1/42 |
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