Safety and efficacy of glibenclamide on functional outcomes in ischemic and hemorrhagic stroke: a systematic review and meta-analysis of randomized clinical trials

Safety and efficacy of glibenclamide on functional outcomes in ischemic and hemorrhagic stroke: a systematic review and meta-analysis of randomized clinical trials

BackgroundSecondary brain injuries, including delayed cerebral ischemia, neuroinflammation, and stroke induced cerebral edema can occur following both ischemic and hemorrhagic strokes, contributing to a negative impact on clinical outcomes. Glibenclamide, a sulfonylurea antidiabetic medication, has...

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Bibliographic Details
Main Authors: Ola Bin Shilash, Hussam Alhathlol, Rana Alduhaysh, Razan Almufarriji, Mohammed Bafaquh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neurology
Subjects:
glibenclamide
stroke
ischemia
SAH
hemorrhage
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1609101/full
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