Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study
Objective We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).Des...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-07-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/7/e022877.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850219131293401088 |
|---|---|
| author | Yoriko Heianza Dianjianyi Sun Lu Qi Louis R Pasquale Jian-Min Yuan Tao Huang Frank B Hu Tiange Wang Janey Wiggs Hyon-Kyoo Choi Jin Fang Chai Xueling Sim Chiea Chuen Khor Yechiel Friedlander Andrew T Chan Gary Curhan Immaculata De Vivo Rob Martinu van Dam Chew Kiat Heng Charles Fuchs Woon Puay Koh |
| author_facet | Yoriko Heianza Dianjianyi Sun Lu Qi Louis R Pasquale Jian-Min Yuan Tao Huang Frank B Hu Tiange Wang Janey Wiggs Hyon-Kyoo Choi Jin Fang Chai Xueling Sim Chiea Chuen Khor Yechiel Friedlander Andrew T Chan Gary Curhan Immaculata De Vivo Rob Martinu van Dam Chew Kiat Heng Charles Fuchs Woon Puay Koh |
| author_sort | Yoriko Heianza |
| collection | DOAJ |
| description | Objective We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).Design Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.Setting Population based study.Participants 11 323 women from the Nurses’ Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women’s Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).Main outcomes Long-term (~10 years) changes in BMI and body weight.Results In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2 per g, p=3×10−5) than the rs174570 non-T carriers (beta=0.16 kg/m2 per g, p=0.08). Similar results were observed for fish intake.Conclusions Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts. |
| format | Article |
| id | doaj-art-4ef346b0c5a1482f87db30c7fbebcf24 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-4ef346b0c5a1482f87db30c7fbebcf242025-08-20T02:07:28ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2018-022877Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort studyYoriko Heianza0Dianjianyi Sun1Lu Qi2Louis R Pasquale3Jian-Min Yuan4Tao Huang5Frank B Hu6Tiange Wang7Janey Wiggs8Hyon-Kyoo Choi9Jin Fang Chai10Xueling Sim11Chiea Chuen Khor12Yechiel Friedlander13Andrew T Chan14Gary Curhan15Immaculata De Vivo16Rob Martinu van Dam17Chew Kiat Heng18Charles Fuchs19Woon Puay Koh201 Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USASchool of Public Health, Peking University, Beijing, China1 Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USAOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USADivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Centre, University of Pittsburgh, Pittsburgh, Pennsylvania, USAImmune-Onc Therapeutics, Inc, Palo Alto, California, USA1 Department of Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USADepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA6 Department of Medicine, Massachusetts General Hospital—Harvard Medical School Center for Nervous System Repair, Boston, Massachusetts, USA7 Department of Medicine, National University Singapore Yong Loo Lin School of Medicine, Singapore, SingaporeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDivision of Infectious Diseases, Genome Institute of Singapore, Singapore10 Unit of Epidemiology, Hebrew University, Ciudad de Mexico, MexicoDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USAResearch, OM1 Inc, Boston, Massachusetts, USA12 Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA13 Department of Epidemiology, National University of Singapore, Singapore, Singapore14 Department of Paediatrics, National University of Singapore, Singapore, Singapore15 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA13 Department of Epidemiology, National University of Singapore, Singapore, SingaporeObjective We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).Design Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.Setting Population based study.Participants 11 323 women from the Nurses’ Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women’s Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).Main outcomes Long-term (~10 years) changes in BMI and body weight.Results In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2 per g, p=3×10−5) than the rs174570 non-T carriers (beta=0.16 kg/m2 per g, p=0.08). Similar results were observed for fish intake.Conclusions Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.https://bmjopen.bmj.com/content/9/7/e022877.full |
| spellingShingle | Yoriko Heianza Dianjianyi Sun Lu Qi Louis R Pasquale Jian-Min Yuan Tao Huang Frank B Hu Tiange Wang Janey Wiggs Hyon-Kyoo Choi Jin Fang Chai Xueling Sim Chiea Chuen Khor Yechiel Friedlander Andrew T Chan Gary Curhan Immaculata De Vivo Rob Martinu van Dam Chew Kiat Heng Charles Fuchs Woon Puay Koh Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study BMJ Open |
| title | Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study |
| title_full | Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study |
| title_fullStr | Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study |
| title_full_unstemmed | Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study |
| title_short | Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study |
| title_sort | fish and marine fatty acids intakes the fads genotypes and long term weight gain a prospective cohort study |
| url | https://bmjopen.bmj.com/content/9/7/e022877.full |
| work_keys_str_mv | AT yorikoheianza fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT dianjianyisun fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT luqi fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT louisrpasquale fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT jianminyuan fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT taohuang fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT frankbhu fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT tiangewang fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT janeywiggs fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT hyonkyoochoi fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT jinfangchai fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT xuelingsim fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT chieachuenkhor fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT yechielfriedlander fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT andrewtchan fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT garycurhan fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT immaculatadevivo fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT robmartinuvandam fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT chewkiatheng fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT charlesfuchs fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy AT woonpuaykoh fishandmarinefattyacidsintakesthefadsgenotypesandlongtermweightgainaprospectivecohortstudy |