Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry

ObjectivesTo detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU).MethodsPredictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME...

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Main Authors: Jurgen Sota, Germán Mejía-Salgado, Silvana Guerriero, Gaafar Ragab, Stefania Costi, Maria Pia Paroli, Andrea Hinojosa-Azaola, Giuseppe Lopalco, Luciana Breda, Henrique Ayres Mayrink Giardini, Alex Fonollosa, Maria Sole Chimenti, Antonio Vitale, Carla Gaggiano, Blanca Aguilar-Barrera, Laura Daniela Rodríguez-Camelo, Guillermo Arturo Guaracha-Basañez, Mohamed Tharwat Hegazy, Rosanna Dammacco, Valeria Albano, Eduardo Martín-Nares, Santiago Espinosa-Lugo, Mahmoud Ghanema, Maria Morrone, Saverio La Bella, Rafael Alves Cordeiro, Francesco Carubbi, Alessandro Conforti, Piero Ruscitti, Ibrahim AlMaglouth, Rosaria Talarico, Stefano Gentileschi, Petros P. Sfikakis, Valeria Caggiano, Matteo Piga, Adele Civino, Francesca Ricci, Maissa Thabet, Marcello Govoni, Abdurrahman Tufan, Francesca Crisafulli, Jessica Sbalchiero, Sulaiman M. Al-Mayouf, Angela Mauro, Soad Hashad, Francesca Minoia, Alma Nunzia Olivieri, Samar Tharwat, Maria Cristina Maggio, Abdelhfeez Moshrif, Gian Domenico Sebastiani, Daniela Opris-Belinski, Gülen Hatemi, Haner Direskeneli, Fatma Alibaz-Öner, Lampros Fotis, José Hernández-Rodríguez, Giovanni Conti, Piercarlo Sarzi Puttini, Ombretta Viapiana, Annarita Giardina, Patrizia Barone, Kalpana Babu, Rana Hussein Amin, Perla Ayumi Kawakami-Campos, Vishali Gupta, Annamaria Iagnocco, Ali Şahin, Antonella Insalaco, Andrés González-García, Ezgi Deniz Batu, Ester Carreño, Emanuela Del Giudice, Cecilia Beatrice Chighizola, Fabrizio Conti, Alberto Balistreri, Bruno Frediani, Luca Cantarini, Alejandra de-la-Torre, Claudia Fabiani
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Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1609613/full
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author Jurgen Sota
Germán Mejía-Salgado
Silvana Guerriero
Gaafar Ragab
Gaafar Ragab
Stefania Costi
Maria Pia Paroli
Andrea Hinojosa-Azaola
Giuseppe Lopalco
Luciana Breda
Henrique Ayres Mayrink Giardini
Alex Fonollosa
Maria Sole Chimenti
Antonio Vitale
Carla Gaggiano
Blanca Aguilar-Barrera
Laura Daniela Rodríguez-Camelo
Guillermo Arturo Guaracha-Basañez
Mohamed Tharwat Hegazy
Mohamed Tharwat Hegazy
Rosanna Dammacco
Valeria Albano
Eduardo Martín-Nares
Santiago Espinosa-Lugo
Mahmoud Ghanema
Maria Morrone
Saverio La Bella
Rafael Alves Cordeiro
Francesco Carubbi
Alessandro Conforti
Piero Ruscitti
Ibrahim AlMaglouth
Rosaria Talarico
Stefano Gentileschi
Petros P. Sfikakis
Valeria Caggiano
Matteo Piga
Adele Civino
Francesca Ricci
Maissa Thabet
Marcello Govoni
Abdurrahman Tufan
Francesca Crisafulli
Jessica Sbalchiero
Sulaiman M. Al-Mayouf
Angela Mauro
Angela Mauro
Soad Hashad
Soad Hashad
Francesca Minoia
Alma Nunzia Olivieri
Samar Tharwat
Samar Tharwat
Maria Cristina Maggio
Abdelhfeez Moshrif
Gian Domenico Sebastiani
Daniela Opris-Belinski
Gülen Hatemi
Gülen Hatemi
Haner Direskeneli
Fatma Alibaz-Öner
Lampros Fotis
José Hernández-Rodríguez
Giovanni Conti
Piercarlo Sarzi Puttini
Ombretta Viapiana
Annarita Giardina
Patrizia Barone
Kalpana Babu
Rana Hussein Amin
Perla Ayumi Kawakami-Campos
Vishali Gupta
Annamaria Iagnocco
Ali Şahin
Antonella Insalaco
Andrés González-García
Ezgi Deniz Batu
Ester Carreño
Emanuela Del Giudice
Cecilia Beatrice Chighizola
Cecilia Beatrice Chighizola
Fabrizio Conti
Alberto Balistreri
Bruno Frediani
Luca Cantarini
Alejandra de-la-Torre
Claudia Fabiani
author_facet Jurgen Sota
Germán Mejía-Salgado
Silvana Guerriero
Gaafar Ragab
Gaafar Ragab
Stefania Costi
Maria Pia Paroli
Andrea Hinojosa-Azaola
Giuseppe Lopalco
Luciana Breda
Henrique Ayres Mayrink Giardini
Alex Fonollosa
Maria Sole Chimenti
Antonio Vitale
Carla Gaggiano
Blanca Aguilar-Barrera
Laura Daniela Rodríguez-Camelo
Guillermo Arturo Guaracha-Basañez
Mohamed Tharwat Hegazy
Mohamed Tharwat Hegazy
Rosanna Dammacco
Valeria Albano
Eduardo Martín-Nares
Santiago Espinosa-Lugo
Mahmoud Ghanema
Maria Morrone
Saverio La Bella
Rafael Alves Cordeiro
Francesco Carubbi
Alessandro Conforti
Piero Ruscitti
Ibrahim AlMaglouth
Rosaria Talarico
Stefano Gentileschi
Petros P. Sfikakis
Valeria Caggiano
Matteo Piga
Adele Civino
Francesca Ricci
Maissa Thabet
Marcello Govoni
Abdurrahman Tufan
Francesca Crisafulli
Jessica Sbalchiero
Sulaiman M. Al-Mayouf
Angela Mauro
Angela Mauro
Soad Hashad
Soad Hashad
Francesca Minoia
Alma Nunzia Olivieri
Samar Tharwat
Samar Tharwat
Maria Cristina Maggio
Abdelhfeez Moshrif
Gian Domenico Sebastiani
Daniela Opris-Belinski
Gülen Hatemi
Gülen Hatemi
Haner Direskeneli
Fatma Alibaz-Öner
Lampros Fotis
José Hernández-Rodríguez
Giovanni Conti
Piercarlo Sarzi Puttini
Ombretta Viapiana
Annarita Giardina
Patrizia Barone
Kalpana Babu
Rana Hussein Amin
Perla Ayumi Kawakami-Campos
Vishali Gupta
Annamaria Iagnocco
Ali Şahin
Antonella Insalaco
Andrés González-García
Ezgi Deniz Batu
Ester Carreño
Emanuela Del Giudice
Cecilia Beatrice Chighizola
Cecilia Beatrice Chighizola
Fabrizio Conti
Alberto Balistreri
Bruno Frediani
Luca Cantarini
Alejandra de-la-Torre
Claudia Fabiani
author_sort Jurgen Sota
collection DOAJ
description ObjectivesTo detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU).MethodsPredictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined.ResultsA total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33).ConclusionME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.
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spelling doaj-art-4ef0a9e2b3b34d6c8ac302ef31a3661b2025-08-20T03:58:49ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16096131609613Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registryJurgen Sota0Germán Mejía-Salgado1Silvana Guerriero2Gaafar Ragab3Gaafar Ragab4Stefania Costi5Maria Pia Paroli6Andrea Hinojosa-Azaola7Giuseppe Lopalco8Luciana Breda9Henrique Ayres Mayrink Giardini10Alex Fonollosa11Maria Sole Chimenti12Antonio Vitale13Carla Gaggiano14Blanca Aguilar-Barrera15Laura Daniela Rodríguez-Camelo16Guillermo Arturo Guaracha-Basañez17Mohamed Tharwat Hegazy18Mohamed Tharwat Hegazy19Rosanna Dammacco20Valeria Albano21Eduardo Martín-Nares22Santiago Espinosa-Lugo23Mahmoud Ghanema24Maria Morrone25Saverio La Bella26Rafael Alves Cordeiro27Francesco Carubbi28Alessandro Conforti29Piero Ruscitti30Ibrahim AlMaglouth31Rosaria Talarico32Stefano Gentileschi33Petros P. Sfikakis34Valeria Caggiano35Matteo Piga36Adele Civino37Francesca Ricci38Maissa Thabet39Marcello Govoni40Abdurrahman Tufan41Francesca Crisafulli42Jessica Sbalchiero43Sulaiman M. Al-Mayouf44Angela Mauro45Angela Mauro46Soad Hashad47Soad Hashad48Francesca Minoia49Alma Nunzia Olivieri50Samar Tharwat51Samar Tharwat52Maria Cristina Maggio53Abdelhfeez Moshrif54Gian Domenico Sebastiani55Daniela Opris-Belinski56Gülen Hatemi57Gülen Hatemi58Haner Direskeneli59Fatma Alibaz-Öner60Lampros Fotis61José Hernández-Rodríguez62Giovanni Conti63Piercarlo Sarzi Puttini64Ombretta Viapiana65Annarita Giardina66Patrizia Barone67Kalpana Babu68Rana Hussein Amin69Perla Ayumi Kawakami-Campos70Vishali Gupta71Annamaria Iagnocco72Ali Şahin73Antonella Insalaco74Andrés González-García75Ezgi Deniz Batu76Ester Carreño77Emanuela Del Giudice78Cecilia Beatrice Chighizola79Cecilia Beatrice Chighizola80Fabrizio Conti81Alberto Balistreri82Bruno Frediani83Luca Cantarini84Alejandra de-la-Torre85Claudia Fabiani86Rheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaDepartment of DiBrain, University of Bari, Bari, ItalyUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, EgyptFaculty of Medicine, Newgiza University, Giza, EgyptUnit of Pediatric Rheumatology, ASST Gaetano Pini-CTO, Milan, ItalyUveitis Unit, Department of Sense Organs, Eye Clinic, Sapienza University of Rome, Rome, ItalyDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy0Department of Paediatrics, University of Chieti-Pescara, Chieti, Italy1Division of Rheumatology, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Universidade de São Paulo, São Paulo, Brazil2Department of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Barakaldo, Spain3Rheumatology, Allergology, and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, EgyptFaculty of Medicine, Newgiza University, Giza, EgyptDepartment of DiBrain, University of Bari, Bari, ItalyDepartment of DiBrain, University of Bari, Bari, ItalyDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy0Department of Paediatrics, University of Chieti-Pescara, Chieti, Italy1Division of Rheumatology, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Universidade de São Paulo, São Paulo, Brazil4Department of Life, Health and Environmental Sciences, Division of Internal Medicine and Nephrology, ASL1 Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy5U.O. Medicina Generale, Ospedale San Paolo di Civitavecchia, Civitavecchia, Rome, Italy6Unit of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy7Unit of Rheumatology, Department of Medicine, King Saud University, Riyadh, Saudi Arabia8Unit of Rheumatology, Azienda Ospedaliero-Universitaria Pisana, Pisa, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy9Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, GreeceRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy0Unit of Rheumatology, Department of Medical Sciences and Public Health, University and AOU of Cagliari, Cagliari, Italy1Unit of Pediatric Rheumatology and Immunology, Vito Fazzi Hospital, Lecce, Italy2Pediatric Clinic, University of Brescia and Spedali Civili di Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Brescia, Italy3Department of Internal Medicine, Faculty of Medicine of Sousse, Farhat Hached University Hospital, University of Sousse, Sousse, Tunisia4Unit of Rheumatology, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy5Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye6Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Brescia, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy7Department of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia8Department of Biomedical and Clinical Sciences, Fatebenefratelli Hospital, Università di Milano, Milan, Italy9Unit of Pediatric Rheumatology, Department of Childhood and Developmental Medicine, Fatebenefratelli-Sacco Hospital, Milan, Italy0Department of Rheumatology, Tripoli Children Hospital, Tripoli, Libya1Department of Rheumatology, University of Tripoli, Tripoli, Libya2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy3Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy4Unit of Rheumatology and Immunology, Department of Internal Medicine, Mansoura University, Mansoura, Egypt5Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt6University Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy7Department of Rheumatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt8U.O.C. Reumatologia, Ospedale San Camillo-Forlanini, Rome, Italy9Department of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania0Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye1Behçet's Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Türkiye2Department of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, Türkiye2Department of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, Türkiye3Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece4Autoinflammatory Diseases Clinical Unit, Department of Autoimmune Diseases, Center of the European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA), Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain5Unit of Pediatric Nephrology and Rheumatology, Azienda Ospedaliero Universitaria (AOU) G Martino, Messina, Italy6Unit of Rheumatology, Ospedale Sacco, Milan, Italy7Unit of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy8UOC Medicina Interna, Ambulatorio di Reumatologia, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy9Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy0Department of Uveitis and Ocular Inflammation, Prabha Eye Clinic and Vittala International Institute of Ophthalmology, Bangalore, India1Department of Opthalmology, Faculty of Medicine, Cairo University, Giza, Egypt2Department of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico3Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India4Academic Rheumatology Center, Dipartimento Scienze Cliniche e Biologiche, Università Degli Studi di Torino, Turin, Italy5Division of Rheumatology, Department of Internal Medicine, Sivas Cumhuriyet University Medical Faculty, Sivas, Türkiye6Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Rome, Italy7Department of Internal Medicine, Autoimmune and Rare Diseases Unit, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, IRYCIS, Madrid, Spain8Unit of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Türkiye9Department of Ophthalmology, Fundación Jiménez Díaz University Hospital (FJD), Madrid, Spain0Unit of Pediatric and Neonatology, Department of Maternal Infantile and Urological Sciences, University of Rome La Sapienza, Rome, Italy1Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milan, Italy2Unit of Pediatric Rheumatology, Azienda Socio-Sanitaria Territoriale (ASST) Gaetano Pini Centro Specialistico Ortopedico Traumatologico (CTO), Milan, Italy3Unit of Rheumatology, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy4Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia5Unit of Ophthalmology, Department of Medicine, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyObjectivesTo detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU).MethodsPredictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined.ResultsA total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33).ConclusionME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.https://www.frontiersin.org/articles/10.3389/fmed.2025.1609613/fulluveitismacular edemavisual acuityregistriesretinal vasculitis
spellingShingle Jurgen Sota
Germán Mejía-Salgado
Silvana Guerriero
Gaafar Ragab
Gaafar Ragab
Stefania Costi
Maria Pia Paroli
Andrea Hinojosa-Azaola
Giuseppe Lopalco
Luciana Breda
Henrique Ayres Mayrink Giardini
Alex Fonollosa
Maria Sole Chimenti
Antonio Vitale
Carla Gaggiano
Blanca Aguilar-Barrera
Laura Daniela Rodríguez-Camelo
Guillermo Arturo Guaracha-Basañez
Mohamed Tharwat Hegazy
Mohamed Tharwat Hegazy
Rosanna Dammacco
Valeria Albano
Eduardo Martín-Nares
Santiago Espinosa-Lugo
Mahmoud Ghanema
Maria Morrone
Saverio La Bella
Rafael Alves Cordeiro
Francesco Carubbi
Alessandro Conforti
Piero Ruscitti
Ibrahim AlMaglouth
Rosaria Talarico
Stefano Gentileschi
Petros P. Sfikakis
Valeria Caggiano
Matteo Piga
Adele Civino
Francesca Ricci
Maissa Thabet
Marcello Govoni
Abdurrahman Tufan
Francesca Crisafulli
Jessica Sbalchiero
Sulaiman M. Al-Mayouf
Angela Mauro
Angela Mauro
Soad Hashad
Soad Hashad
Francesca Minoia
Alma Nunzia Olivieri
Samar Tharwat
Samar Tharwat
Maria Cristina Maggio
Abdelhfeez Moshrif
Gian Domenico Sebastiani
Daniela Opris-Belinski
Gülen Hatemi
Gülen Hatemi
Haner Direskeneli
Fatma Alibaz-Öner
Lampros Fotis
José Hernández-Rodríguez
Giovanni Conti
Piercarlo Sarzi Puttini
Ombretta Viapiana
Annarita Giardina
Patrizia Barone
Kalpana Babu
Rana Hussein Amin
Perla Ayumi Kawakami-Campos
Vishali Gupta
Annamaria Iagnocco
Ali Şahin
Antonella Insalaco
Andrés González-García
Ezgi Deniz Batu
Ester Carreño
Emanuela Del Giudice
Cecilia Beatrice Chighizola
Cecilia Beatrice Chighizola
Fabrizio Conti
Alberto Balistreri
Bruno Frediani
Luca Cantarini
Alejandra de-la-Torre
Claudia Fabiani
Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
Frontiers in Medicine
uveitis
macular edema
visual acuity
registries
retinal vasculitis
title Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
title_full Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
title_fullStr Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
title_full_unstemmed Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
title_short Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
title_sort predictors of uveitic macular edema and functional prognostic outcomes real life data from the international aida network uveitis registry
topic uveitis
macular edema
visual acuity
registries
retinal vasculitis
url https://www.frontiersin.org/articles/10.3389/fmed.2025.1609613/full
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