A comprehensive review and advanced biomolecule-based therapies for osteoporosis

Background: The prevalence of osteoporosis (OP) on a global scale is significantly elevated that causes life threatening issues. The potential of groundbreaking biomolecular therapeutics in the field of OP is highly encouraging. The administration of biomolecular agents has the potential to mitigate...

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Main Authors: Maqsood Ali, Yong-Sik Kim
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002157
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author Maqsood Ali
Yong-Sik Kim
author_facet Maqsood Ali
Yong-Sik Kim
author_sort Maqsood Ali
collection DOAJ
description Background: The prevalence of osteoporosis (OP) on a global scale is significantly elevated that causes life threatening issues. The potential of groundbreaking biomolecular therapeutics in the field of OP is highly encouraging. The administration of biomolecular agents has the potential to mitigate the process of bone demineralization while concurrently augmenting the regenerative capacity of bone tissue, thereby facilitating a personalized therapeutic approach. Biomolecules-based therapies showed promising results in term of bone mass protection and restoration in OP. Aim of review: We summarized the recent biomolecular therapies with notable progress in clinical, demonstrating the potential to transform illness management. These treatments frequently utilize different biomolecule based strategies. Biomolecular therapeutics has a targeted character, which results in heightened specificity and less off-target effects, ultimately leading to increased patient outcomes. These aspects have the capacity to greatly enhance the management of OP, thus resulting in a major enhancement in the quality of life encountered by individuals affected by this condition.
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spelling doaj-art-4eee1e277d474c1db8c0abe397f8a21d2025-08-20T02:19:51ZengElsevierJournal of Advanced Research2090-12322025-05-017133735410.1016/j.jare.2024.05.024A comprehensive review and advanced biomolecule-based therapies for osteoporosisMaqsood Ali0Yong-Sik Kim1Department of Microbiology, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of KoreaDepartment of Microbiology, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of Korea; Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of Korea; Corresponding author at: Department of Microbiology, College of Medicine, Soonchunhyang University, Soonchunhyang 6 gil 31, Dongnam-Gu, Cheonan, Chung-nam 31151, Republic of Korea.Background: The prevalence of osteoporosis (OP) on a global scale is significantly elevated that causes life threatening issues. The potential of groundbreaking biomolecular therapeutics in the field of OP is highly encouraging. The administration of biomolecular agents has the potential to mitigate the process of bone demineralization while concurrently augmenting the regenerative capacity of bone tissue, thereby facilitating a personalized therapeutic approach. Biomolecules-based therapies showed promising results in term of bone mass protection and restoration in OP. Aim of review: We summarized the recent biomolecular therapies with notable progress in clinical, demonstrating the potential to transform illness management. These treatments frequently utilize different biomolecule based strategies. Biomolecular therapeutics has a targeted character, which results in heightened specificity and less off-target effects, ultimately leading to increased patient outcomes. These aspects have the capacity to greatly enhance the management of OP, thus resulting in a major enhancement in the quality of life encountered by individuals affected by this condition.http://www.sciencedirect.com/science/article/pii/S2090123224002157BiomoleculesBone regenerationOsteogenesisOsteoporosis
spellingShingle Maqsood Ali
Yong-Sik Kim
A comprehensive review and advanced biomolecule-based therapies for osteoporosis
Journal of Advanced Research
Biomolecules
Bone regeneration
Osteogenesis
Osteoporosis
title A comprehensive review and advanced biomolecule-based therapies for osteoporosis
title_full A comprehensive review and advanced biomolecule-based therapies for osteoporosis
title_fullStr A comprehensive review and advanced biomolecule-based therapies for osteoporosis
title_full_unstemmed A comprehensive review and advanced biomolecule-based therapies for osteoporosis
title_short A comprehensive review and advanced biomolecule-based therapies for osteoporosis
title_sort comprehensive review and advanced biomolecule based therapies for osteoporosis
topic Biomolecules
Bone regeneration
Osteogenesis
Osteoporosis
url http://www.sciencedirect.com/science/article/pii/S2090123224002157
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