Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review
Background. Pleomorphic sarcoma is an aggressive soft tissue sarcoma. In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported. To our knowledge, this is the first report in the literat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/320797 |
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| author | Markus K. Schuler Stephan Richter Ivan Platzek Bettina Beuthien-Baumann Kathrin Wieczorek Christine Hamann Johannes Mohm Gerhard Ehninger |
| author_facet | Markus K. Schuler Stephan Richter Ivan Platzek Bettina Beuthien-Baumann Kathrin Wieczorek Christine Hamann Johannes Mohm Gerhard Ehninger |
| author_sort | Markus K. Schuler |
| collection | DOAJ |
| description | Background. Pleomorphic sarcoma is an aggressive soft tissue sarcoma. In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported. To our knowledge, this is the first report in the literature of the neoadjuvant use of trabectedin in a patient with high-grade pleomorphic sarcoma, ineligible for standard neoadjuvant combination therapy with an anthracycline-based regimen. Case Presentation. Here we present a 58-year-old White male with a large tumor in the left thigh, but with no signs of metastases. Owing to the history of severe heart attack, three cycles of neoadjuvant trabectedin were administrated to achieve surgically wide margins. After two cycles, an 18F-FDG-PET showed a large proportion of the central tumor area was without metabolic activity. According to RECIST and Choi criteria, the tumor was stable. After the third cycle of trabectedin, the patient underwent a complete resection, which revealed completely necrotic high-grade pleomorphic sarcoma (stage pT2b), with only a small vital area. Conclusion. The present paper on a promising treatment with neoadjuvant trabectedin of patients with high-grade pleomorphic sarcoma might suggest that such treatment approach may provide a greater chance of cure and survival of such patients. |
| format | Article |
| id | doaj-art-4ee7db77176e4e059c199167fc4b6cb5 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4ee7db77176e4e059c199167fc4b6cb52025-08-20T02:05:35ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/320797320797Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature ReviewMarkus K. Schuler0Stephan Richter1Ivan Platzek2Bettina Beuthien-Baumann3Kathrin Wieczorek4Christine Hamann5Johannes Mohm6Gerhard Ehninger7Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyDepartment of Radiology, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyDepartment of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyDepartment of Pathology, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyDepartment of Orthopaedics, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyHämatologisch-Onkologische Praxis, Dresden, GermanyDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, GermanyBackground. Pleomorphic sarcoma is an aggressive soft tissue sarcoma. In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported. To our knowledge, this is the first report in the literature of the neoadjuvant use of trabectedin in a patient with high-grade pleomorphic sarcoma, ineligible for standard neoadjuvant combination therapy with an anthracycline-based regimen. Case Presentation. Here we present a 58-year-old White male with a large tumor in the left thigh, but with no signs of metastases. Owing to the history of severe heart attack, three cycles of neoadjuvant trabectedin were administrated to achieve surgically wide margins. After two cycles, an 18F-FDG-PET showed a large proportion of the central tumor area was without metabolic activity. According to RECIST and Choi criteria, the tumor was stable. After the third cycle of trabectedin, the patient underwent a complete resection, which revealed completely necrotic high-grade pleomorphic sarcoma (stage pT2b), with only a small vital area. Conclusion. The present paper on a promising treatment with neoadjuvant trabectedin of patients with high-grade pleomorphic sarcoma might suggest that such treatment approach may provide a greater chance of cure and survival of such patients.http://dx.doi.org/10.1155/2013/320797 |
| spellingShingle | Markus K. Schuler Stephan Richter Ivan Platzek Bettina Beuthien-Baumann Kathrin Wieczorek Christine Hamann Johannes Mohm Gerhard Ehninger Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review Case Reports in Oncological Medicine |
| title | Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review |
| title_full | Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review |
| title_fullStr | Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review |
| title_full_unstemmed | Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review |
| title_short | Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review |
| title_sort | trabectedin in the neoadjuvant treatment of high grade pleomorphic sarcoma report of a rare case and literature review |
| url | http://dx.doi.org/10.1155/2013/320797 |
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