Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model
The authors of this study focused their research on developing cap geometries for the FibroScan<sup>®</sup> elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig animal model. Numerical models...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Livers |
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| Online Access: | https://www.mdpi.com/2673-4389/5/1/3 |
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| author | Dariusz Pyka Agnieszka Noszczyk-Nowak Karina Krawiec Tomasz Świetlik Krzysztof J. Opieliński |
| author_facet | Dariusz Pyka Agnieszka Noszczyk-Nowak Karina Krawiec Tomasz Świetlik Krzysztof J. Opieliński |
| author_sort | Dariusz Pyka |
| collection | DOAJ |
| description | The authors of this study focused their research on developing cap geometries for the FibroScan<sup>®</sup> elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig animal model. Numerical models were created to simulate the propagation of a mechanical wave through a biological medium induced by the FibroScan<sup>®</sup> elastograph measuring head. The designed caps were intended to replicate the skin–muscle–rib–liver structures to minimize the risk of damage caused by mechanical wave excitation when directly applied to liver tissue. The construction process of numerical models for the liver and surrounding tissues is presented, along with simulations reflecting the mechanical and acoustic properties of the wave propagation process. The results obtained from in vivo measurements on pigs were validated through a numerical analysis, confirming a high level of agreement between the test results and the numerical model. |
| format | Article |
| id | doaj-art-4ee575fe14054b57baebc05c7679bb10 |
| institution | OA Journals |
| issn | 2673-4389 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj-art-4ee575fe14054b57baebc05c7679bb102025-08-20T01:48:57ZengMDPI AGLivers2673-43892025-01-0151310.3390/livers5010003Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine ModelDariusz Pyka0Agnieszka Noszczyk-Nowak1Karina Krawiec2Tomasz Świetlik3Krzysztof J. Opieliński4Department of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, Smoluchowskiego 25 Str., 50-370 Wroclaw, PolandDivision of Translational Medicine, Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Grunwaldzki sq. 47, 50-366 Wrocław, PolandDepartment of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, Smoluchowskiego 25 Str., 50-370 Wroclaw, PolandDepartment of Acoustics, Multimedia and Signal Processing, Faculty of Electronics, Photonics and Microsystems, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 2627, 50-370 Wroclaw, PolandDepartment of Acoustics, Multimedia and Signal Processing, Faculty of Electronics, Photonics and Microsystems, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 2627, 50-370 Wroclaw, PolandThe authors of this study focused their research on developing cap geometries for the FibroScan<sup>®</sup> elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig animal model. Numerical models were created to simulate the propagation of a mechanical wave through a biological medium induced by the FibroScan<sup>®</sup> elastograph measuring head. The designed caps were intended to replicate the skin–muscle–rib–liver structures to minimize the risk of damage caused by mechanical wave excitation when directly applied to liver tissue. The construction process of numerical models for the liver and surrounding tissues is presented, along with simulations reflecting the mechanical and acoustic properties of the wave propagation process. The results obtained from in vivo measurements on pigs were validated through a numerical analysis, confirming a high level of agreement between the test results and the numerical model.https://www.mdpi.com/2673-4389/5/1/3elastographypig liverFibroScan<sup>®</sup>liver fibrosisFEM/SPH analysis |
| spellingShingle | Dariusz Pyka Agnieszka Noszczyk-Nowak Karina Krawiec Tomasz Świetlik Krzysztof J. Opieliński Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model Livers elastography pig liver FibroScan<sup>®</sup> liver fibrosis FEM/SPH analysis |
| title | Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model |
| title_full | Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model |
| title_fullStr | Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model |
| title_full_unstemmed | Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model |
| title_short | Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model |
| title_sort | innovative elastography measuring cap for ex vivo liver condition assessment numerical and preclinical studies in a porcine model |
| topic | elastography pig liver FibroScan<sup>®</sup> liver fibrosis FEM/SPH analysis |
| url | https://www.mdpi.com/2673-4389/5/1/3 |
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