Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity
This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives of 6- methyl 2-thiouracil. The preparation process started by the reaction of 6- methyl 2-thiouracil with ethyl chloroacete to give ethyl 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1)...
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| Language: | English |
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Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/630 |
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| author | Khalid M. Mohammad Mohammad R. Ahmed Mahmoud H. Mahmoud |
| author_facet | Khalid M. Mohammad Mohammad R. Ahmed Mahmoud H. Mahmoud |
| author_sort | Khalid M. Mohammad |
| collection | DOAJ |
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This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives of 6- methyl 2-thiouracil. The preparation process started by the reaction of 6- methyl 2-thiouracil with ethyl chloroacete to give ethyl 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1) reacted with hydrazine hydrate to give 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio) aceto hydrazide (2). That reacted with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new Schiff bases derivatives (3-11). The new 1,3-oxazepine derivatives [12-38] were obtained from treatment of each new Schiff bases derivatives (3-11) with each (phthalic anhydride ,maleic anhydride and succinic anhydride) respectively. Newly synthesized compounds were identified via spectral methods; their [FT-IR and some of them by 1H-NMR, 13C-NMR] and measurements of some of its physical properties. Furthermore some of the new compounds were screened for their antimicrobial activity against four strains of bacteria –ve (Escherichia coli and klibsialla) and +ve (Bacillus and Staphylococcus aureus). Most of the tested compounds show significant antibacterial activity.
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| format | Article |
| id | doaj-art-4ee452c24f7d456a8131b7db187da015 |
| institution | DOAJ |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-4ee452c24f7d456a8131b7db187da0152025-08-20T03:16:51ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-01-0122210.25130/tjps.v22i2.630Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activityKhalid M. MohammadMohammad R. AhmedMahmoud H. Mahmoud This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives of 6- methyl 2-thiouracil. The preparation process started by the reaction of 6- methyl 2-thiouracil with ethyl chloroacete to give ethyl 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1) reacted with hydrazine hydrate to give 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio) aceto hydrazide (2). That reacted with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new Schiff bases derivatives (3-11). The new 1,3-oxazepine derivatives [12-38] were obtained from treatment of each new Schiff bases derivatives (3-11) with each (phthalic anhydride ,maleic anhydride and succinic anhydride) respectively. Newly synthesized compounds were identified via spectral methods; their [FT-IR and some of them by 1H-NMR, 13C-NMR] and measurements of some of its physical properties. Furthermore some of the new compounds were screened for their antimicrobial activity against four strains of bacteria –ve (Escherichia coli and klibsialla) and +ve (Bacillus and Staphylococcus aureus). Most of the tested compounds show significant antibacterial activity. https://tjpsj.org/index.php/tjps/article/view/6306- methyl 2- thiouracilshichff bases1,3 oxazepin derivativeantibacterial |
| spellingShingle | Khalid M. Mohammad Mohammad R. Ahmed Mahmoud H. Mahmoud Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity Tikrit Journal of Pure Science 6- methyl 2- thiouracil shichff bases 1,3 oxazepin derivative antibacterial |
| title | Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity |
| title_full | Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity |
| title_fullStr | Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity |
| title_full_unstemmed | Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity |
| title_short | Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity |
| title_sort | synthesis and characterization of some new 1 3 oxazepine derivative from 6 methyl 2 thiouracil and study their biological activity |
| topic | 6- methyl 2- thiouracil shichff bases 1,3 oxazepin derivative antibacterial |
| url | https://tjpsj.org/index.php/tjps/article/view/630 |
| work_keys_str_mv | AT khalidmmohammad synthesisandcharacterizationofsomenew13oxazepinederivativefrom6methyl2thiouracilandstudytheirbiologicalactivity AT mohammadrahmed synthesisandcharacterizationofsomenew13oxazepinederivativefrom6methyl2thiouracilandstudytheirbiologicalactivity AT mahmoudhmahmoud synthesisandcharacterizationofsomenew13oxazepinederivativefrom6methyl2thiouracilandstudytheirbiologicalactivity |