Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair
Wound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins....
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| Format: | Article |
| Language: | English |
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Interna Publishing
2017-05-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/200 |
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| author | Indah Julianto Yuyun Rindastuti |
| author_facet | Indah Julianto Yuyun Rindastuti |
| author_sort | Indah Julianto |
| collection | DOAJ |
| description | Wound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases. The beneficial effect of exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate stalled healing processes. Recent studies revealed that human placental membranes are a rich source of MSCs for tissue regeneration and repair. This review provides a concise summary of current knowledge of biological properties of MSCs and describes the use of MSCs for wound healing. In particular, the scope of this review focuses on the role MSCs have in each phase of the wound-healing process, and clinical reports transplatation MSCs – secretomes in chronical ulcer. |
| format | Article |
| id | doaj-art-4ee2ef0ba3fa45378458523fbdaeaa54 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-4ee2ef0ba3fa45378458523fbdaeaa542025-08-20T02:48:12ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322017-05-01483Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound RepairIndah Julianto0Yuyun Rindastuti1Dermato Venereology Department Medical Faculty Sebelas Maret, University dr. Moewardi General Hospital, SurakartaStem Cell Programm, National South Korea University-South KoreaWound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases. The beneficial effect of exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate stalled healing processes. Recent studies revealed that human placental membranes are a rich source of MSCs for tissue regeneration and repair. This review provides a concise summary of current knowledge of biological properties of MSCs and describes the use of MSCs for wound healing. In particular, the scope of this review focuses on the role MSCs have in each phase of the wound-healing process, and clinical reports transplatation MSCs – secretomes in chronical ulcer.https://actamedindones.org/index.php/ijim/article/view/200mesenchymal stem cellssecretomestissue regenerationchronical ulcer |
| spellingShingle | Indah Julianto Yuyun Rindastuti Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair Acta Medica Indonesiana mesenchymal stem cells secretomes tissue regeneration chronical ulcer |
| title | Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair |
| title_full | Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair |
| title_fullStr | Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair |
| title_full_unstemmed | Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair |
| title_short | Topical Delivery of Mesenchymal Stem Cells “Secretomes” in Wound Repair |
| title_sort | topical delivery of mesenchymal stem cells secretomes in wound repair |
| topic | mesenchymal stem cells secretomes tissue regeneration chronical ulcer |
| url | https://actamedindones.org/index.php/ijim/article/view/200 |
| work_keys_str_mv | AT indahjulianto topicaldeliveryofmesenchymalstemcellssecretomesinwoundrepair AT yuyunrindastuti topicaldeliveryofmesenchymalstemcellssecretomesinwoundrepair |