Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway

Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway

Abstract Papillary thyroid cancer (PTC), the predominant thyroid cancer, exhibits different adverse outcomes. However, the underlying molecular mechanisms of PTC remain inadequately elucidated. An integrative analysis of multiple mRNA-seq datasets from Gene Expression Omnibus and The Cancer Genome A...

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Main Authors: Fengping Wu, Qian Liu, Jinkang Zhang, Dongkun Xu, Xue Jiang, Kun Zhang, YaZheng Chen, Xuliang Xia, Zhiqiang Jiang, Yuhong Shi, Wenling Tu
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07702-0
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