The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study
Background Critically ill patients in the intensive care unit (ICU) often experience dysglycaemia. However, studies investigating the link between acute kidney injury (AKI) and dysglycaemia, especially in those with and without diabetes mellitus (DM), are limited.Methods We used the Medical Informat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2397555 |
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| author | Chong Zhang Meng Ning Weiru Liang Wei Su Yi Chen Tingting Guo Kun Hu Wenjin Peng Yingwu Liu |
| author_facet | Chong Zhang Meng Ning Weiru Liang Wei Su Yi Chen Tingting Guo Kun Hu Wenjin Peng Yingwu Liu |
| author_sort | Chong Zhang |
| collection | DOAJ |
| description | Background Critically ill patients in the intensive care unit (ICU) often experience dysglycaemia. However, studies investigating the link between acute kidney injury (AKI) and dysglycaemia, especially in those with and without diabetes mellitus (DM), are limited.Methods We used the Medical Information Mart for Intensive Care IV database to investigate the association between AKI within 7 days of admission and subsequent dysglycaemia. The primary outcome was the occurrence of dysglycaemia (both hypoglycemia and hyperglycemia) after 7 days of ICU admission. Logistic regression analyzed the relationship between AKI and dysglycaemia, while a Cox proportional hazards model estimated the long-term mortality risk linked to the AKI combined with dysglycaemia.Results A cohort of 20,008 critically ill patients were included. The AKI group demonstrated a higher prevalence of dysglycaemia, compared to the non-AKI group. AKI patients had an increased risk of dysglycaemia (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.41–1.65), hypoglycemia (aOR 1.56, 95% CI 1.41–1.73), and hyperglycemia (aOR 1.53, 95% CI 1.41–1.66). In subgroup analysis, compared to DM patients, AKI showed higher risk of dysglycaemia in non-DM patients (aOR: 1.93 vs. 1.33, Pint<0.01). Additionally, the AKI with dysglycaemia group exhibited a higher risk of long-term mortality compared to the non-AKI without dysglycaemia group. Dysglycaemia also mediated the relationship between AKI and long-term mortality.Conclusion AKI was associated with a higher risk of dysglycaemia, especially in non-DM patients, and the combination of AKI and dysglycaemia was linked to higher long-term mortality. Further research is needed to develop optimal glycemic control strategies for AKI patients. |
| format | Article |
| id | doaj-art-4eda2775dd5e4c21871b191d159912e9 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-4eda2775dd5e4c21871b191d159912e92025-08-20T03:22:00ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2397555The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center studyChong Zhang0Meng Ning1Weiru Liang2Wei Su3Yi Chen4Tingting Guo5Kun Hu6Wenjin Peng7Yingwu Liu8The Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaThe Third Central Clinical College of Tianjin Medical University, Tianjin, ChinaBackground Critically ill patients in the intensive care unit (ICU) often experience dysglycaemia. However, studies investigating the link between acute kidney injury (AKI) and dysglycaemia, especially in those with and without diabetes mellitus (DM), are limited.Methods We used the Medical Information Mart for Intensive Care IV database to investigate the association between AKI within 7 days of admission and subsequent dysglycaemia. The primary outcome was the occurrence of dysglycaemia (both hypoglycemia and hyperglycemia) after 7 days of ICU admission. Logistic regression analyzed the relationship between AKI and dysglycaemia, while a Cox proportional hazards model estimated the long-term mortality risk linked to the AKI combined with dysglycaemia.Results A cohort of 20,008 critically ill patients were included. The AKI group demonstrated a higher prevalence of dysglycaemia, compared to the non-AKI group. AKI patients had an increased risk of dysglycaemia (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.41–1.65), hypoglycemia (aOR 1.56, 95% CI 1.41–1.73), and hyperglycemia (aOR 1.53, 95% CI 1.41–1.66). In subgroup analysis, compared to DM patients, AKI showed higher risk of dysglycaemia in non-DM patients (aOR: 1.93 vs. 1.33, Pint<0.01). Additionally, the AKI with dysglycaemia group exhibited a higher risk of long-term mortality compared to the non-AKI without dysglycaemia group. Dysglycaemia also mediated the relationship between AKI and long-term mortality.Conclusion AKI was associated with a higher risk of dysglycaemia, especially in non-DM patients, and the combination of AKI and dysglycaemia was linked to higher long-term mortality. Further research is needed to develop optimal glycemic control strategies for AKI patients.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2397555Acute kidney injurydysglycaemiahypoglycemiahyperglycemiadiabetes mellituslong-term mortality |
| spellingShingle | Chong Zhang Meng Ning Weiru Liang Wei Su Yi Chen Tingting Guo Kun Hu Wenjin Peng Yingwu Liu The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study Renal Failure Acute kidney injury dysglycaemia hypoglycemia hyperglycemia diabetes mellitus long-term mortality |
| title | The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study |
| title_full | The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study |
| title_fullStr | The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study |
| title_full_unstemmed | The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study |
| title_short | The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study |
| title_sort | association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus a retrospective single center study |
| topic | Acute kidney injury dysglycaemia hypoglycemia hyperglycemia diabetes mellitus long-term mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2397555 |
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