An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel, demyelinating disease presenting with optic neuritis, along with other central nervous pathologies. First implicated in 2007, it remains a rare disease, with a prevalence of roughly 1.3 per 1 million adults. We present a case o...
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Elsevier
2025-07-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S193004332500353X |
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| author | Mark A. Colantonio, MD Danielle Sblendorio, MD Elizabeth Hart, MD Joshua Wiley, DO |
| author_facet | Mark A. Colantonio, MD Danielle Sblendorio, MD Elizabeth Hart, MD Joshua Wiley, DO |
| author_sort | Mark A. Colantonio, MD |
| collection | DOAJ |
| description | Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel, demyelinating disease presenting with optic neuritis, along with other central nervous pathologies. First implicated in 2007, it remains a rare disease, with a prevalence of roughly 1.3 per 1 million adults. We present a case of MOGAD in a young female presenting to our rural healthcare facility with endorsements of eye pain and blurred vision. Imaging revealed findings consistent with optic neuritis, as well as hyperintensities of her cerebrum and cervical spine. Distinguishing radiographic features from other neurological pathologies, including conus medullaris enhancement, were not present, highlighting the importance of considering the clinical picture as a whole. We aim to bring awareness to this rare disease, especially to those practitioners localized to a rural environment. |
| format | Article |
| id | doaj-art-4ed8ef72cfd34f66ae16ca21965cc633 |
| institution | OA Journals |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-4ed8ef72cfd34f66ae16ca21965cc6332025-08-20T02:31:29ZengElsevierRadiology Case Reports1930-04332025-07-012073628363110.1016/j.radcr.2025.04.048An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD)Mark A. Colantonio, MD0Danielle Sblendorio, MD1Elizabeth Hart, MD2Joshua Wiley, DO3Department of Medicine, West Virginia University, Morgantown, WV, USA; Corresponding author.Department of Neurology, West Virginia University, Morgantown, WV, USADepartment of Medicine, West Virginia University, Morgantown, WV, USADepartment of Medicine, West Virginia University, Morgantown, WV, USAMyelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel, demyelinating disease presenting with optic neuritis, along with other central nervous pathologies. First implicated in 2007, it remains a rare disease, with a prevalence of roughly 1.3 per 1 million adults. We present a case of MOGAD in a young female presenting to our rural healthcare facility with endorsements of eye pain and blurred vision. Imaging revealed findings consistent with optic neuritis, as well as hyperintensities of her cerebrum and cervical spine. Distinguishing radiographic features from other neurological pathologies, including conus medullaris enhancement, were not present, highlighting the importance of considering the clinical picture as a whole. We aim to bring awareness to this rare disease, especially to those practitioners localized to a rural environment.http://www.sciencedirect.com/science/article/pii/S193004332500353XMyelin oligodendrocyte glycoprotein antibody diseaseOptic neuritisDemyelinationMagnetic resonance imaging |
| spellingShingle | Mark A. Colantonio, MD Danielle Sblendorio, MD Elizabeth Hart, MD Joshua Wiley, DO An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) Radiology Case Reports Myelin oligodendrocyte glycoprotein antibody disease Optic neuritis Demyelination Magnetic resonance imaging |
| title | An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) |
| title_full | An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) |
| title_fullStr | An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) |
| title_full_unstemmed | An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) |
| title_short | An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) |
| title_sort | atypical cause of optic neuritis myelin oligodendrocyte glycoprotein antibody disease mogad |
| topic | Myelin oligodendrocyte glycoprotein antibody disease Optic neuritis Demyelination Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S193004332500353X |
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