Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis
Abstract Background Previous studies reported that patients with asthma showed higher levels of interleukin (IL)‐33 in peripheral blood, compared to healthy control (HCs). However, we also noticed that there were no significant differences of IL‐33 levels between controls and asthma patients in a re...
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Wiley
2023-04-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.842 |
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| author | Ranran Zhao Yun Shi Na Liu Bin Li |
| author_facet | Ranran Zhao Yun Shi Na Liu Bin Li |
| author_sort | Ranran Zhao |
| collection | DOAJ |
| description | Abstract Background Previous studies reported that patients with asthma showed higher levels of interleukin (IL)‐33 in peripheral blood, compared to healthy control (HCs). However, we also noticed that there were no significant differences of IL‐33 levels between controls and asthma patients in a recent study. We aim to conduct this meta‐analysis and evaluate the feasibility of IL‐33 in peripheral blood that may act as a promising biomarker in asthma. Methods Articles published before December 2022 were searched in these databases (PubMed, Web of Science, EMBASE, and Google Scholar). We used STATA 12.0 software to compute the results. Results The study showed that asthmatics showed higher IL‐33 level in serum and plasma, compared to HCs (serum: standard mean difference [SMD] 2.06, 95% confidence interval [CI] 1.12−3.00, I2 = 98.4%, p < .001; plasma: SMD 3.67, 95% CI 2.32−5.03, I2 = 86.0%, p < .001). Subgroup analysis indicated that asthma adults showed higher IL‐33 level in serum, compared to HCs, whereas no significant difference in IL‐33 level in serum was showed between asthma children and HCs (adults: SMD 2.17, 95% CI 1.09−3.25; children: SMD 1.81, 95% CI −0.11 to 3.74). The study indicated that moderate and severe asthmatics showed higher IL‐33 level in serum, compared to mild asthmatics (SMD 0.78, 95% CI 0.41−1.16, I2 = 66.2%, p = .011). Conclusions In conclusion, the main findings of present meta‐analysis suggested that there was a significant correlation between IL‐33 levels and the severity of asthma. Therefore, IL‐33 levels of either serum or plasma may be regarded as a useful biomarker of asthma or the degree of disease. |
| format | Article |
| id | doaj-art-4ed32fd8f604415790f4c5fd91bfc6b3 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
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| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-4ed32fd8f604415790f4c5fd91bfc6b32025-08-20T02:16:50ZengWileyImmunity, Inflammation and Disease2050-45272023-04-01114n/an/a10.1002/iid3.842Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysisRanran Zhao0Yun Shi1Na Liu2Bin Li3Department of Respiratory Medicine Capital Medical University Affiliated Beijing Friendship Hospital Beijing ChinaMedical and Health Center Capital Medical University Affiliated Beijing Friendship Hospital Beijing ChinaDepartment of Respiratory Medicine Beijing Hepingli hospital Beijing ChinaDepartment of Respiratory Medicine Capital Medical University Affiliated Beijing Friendship Hospital Beijing ChinaAbstract Background Previous studies reported that patients with asthma showed higher levels of interleukin (IL)‐33 in peripheral blood, compared to healthy control (HCs). However, we also noticed that there were no significant differences of IL‐33 levels between controls and asthma patients in a recent study. We aim to conduct this meta‐analysis and evaluate the feasibility of IL‐33 in peripheral blood that may act as a promising biomarker in asthma. Methods Articles published before December 2022 were searched in these databases (PubMed, Web of Science, EMBASE, and Google Scholar). We used STATA 12.0 software to compute the results. Results The study showed that asthmatics showed higher IL‐33 level in serum and plasma, compared to HCs (serum: standard mean difference [SMD] 2.06, 95% confidence interval [CI] 1.12−3.00, I2 = 98.4%, p < .001; plasma: SMD 3.67, 95% CI 2.32−5.03, I2 = 86.0%, p < .001). Subgroup analysis indicated that asthma adults showed higher IL‐33 level in serum, compared to HCs, whereas no significant difference in IL‐33 level in serum was showed between asthma children and HCs (adults: SMD 2.17, 95% CI 1.09−3.25; children: SMD 1.81, 95% CI −0.11 to 3.74). The study indicated that moderate and severe asthmatics showed higher IL‐33 level in serum, compared to mild asthmatics (SMD 0.78, 95% CI 0.41−1.16, I2 = 66.2%, p = .011). Conclusions In conclusion, the main findings of present meta‐analysis suggested that there was a significant correlation between IL‐33 levels and the severity of asthma. Therefore, IL‐33 levels of either serum or plasma may be regarded as a useful biomarker of asthma or the degree of disease.https://doi.org/10.1002/iid3.842asthmainterleukin‐33meta‐analysisserumsystematic review |
| spellingShingle | Ranran Zhao Yun Shi Na Liu Bin Li Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis Immunity, Inflammation and Disease asthma interleukin‐33 meta‐analysis serum systematic review |
| title | Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis |
| title_full | Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis |
| title_fullStr | Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis |
| title_full_unstemmed | Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis |
| title_short | Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis |
| title_sort | elevated levels of interleukin 33 are associated with asthma a meta analysis |
| topic | asthma interleukin‐33 meta‐analysis serum systematic review |
| url | https://doi.org/10.1002/iid3.842 |
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