The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses
On February 12th 1973, Bliss and Lomo submitted their findings on activity-dependent plasticity of glutamatergic synapses. After this groundbreaking discovery, long-term potentiation (LTP) and depression (LTD) gained center stage in the study of learning, memory, and experience-dependent refinement...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/254724 |
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| author | Arianna Maffei |
| author_facet | Arianna Maffei |
| author_sort | Arianna Maffei |
| collection | DOAJ |
| description | On February 12th 1973, Bliss and Lomo submitted their findings on activity-dependent plasticity of glutamatergic synapses. After this groundbreaking discovery, long-term potentiation (LTP) and depression (LTD) gained center stage in the study of learning, memory, and experience-dependent refinement of neural circuits. While LTP and LTD are extensively studied and their relevance to brain function is widely accepted, new experimental and theoretical work recently demonstrates that brain development and function relies on additional forms of plasticity, some of which occur at nonglutamatergic synapses. The strength of GABAergic synapses is modulated by activity, and new functions for inhibitory synaptic plasticity are emerging. Together with excitatory neurons, inhibitory neurons shape the excitability and dynamic range of neural circuits. Thus, the understanding of inhibitory synaptic plasticity is crucial to fully comprehend the physiology of brain circuits. Here, I will review recent findings about plasticity at GABAergic synapses and discuss how it may contribute to circuit function. |
| format | Article |
| id | doaj-art-4ecddaa163754a65801d585e31d4d050 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-4ecddaa163754a65801d585e31d4d0502025-02-03T01:27:12ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/254724254724The Many Forms and Functions of Long Term Plasticity at GABAergic SynapsesArianna Maffei0Department of Neurobiology and Behavior, State University of New York (SUNY), Life Science Building Rm 546, Stony Brook, NY 11794, USAOn February 12th 1973, Bliss and Lomo submitted their findings on activity-dependent plasticity of glutamatergic synapses. After this groundbreaking discovery, long-term potentiation (LTP) and depression (LTD) gained center stage in the study of learning, memory, and experience-dependent refinement of neural circuits. While LTP and LTD are extensively studied and their relevance to brain function is widely accepted, new experimental and theoretical work recently demonstrates that brain development and function relies on additional forms of plasticity, some of which occur at nonglutamatergic synapses. The strength of GABAergic synapses is modulated by activity, and new functions for inhibitory synaptic plasticity are emerging. Together with excitatory neurons, inhibitory neurons shape the excitability and dynamic range of neural circuits. Thus, the understanding of inhibitory synaptic plasticity is crucial to fully comprehend the physiology of brain circuits. Here, I will review recent findings about plasticity at GABAergic synapses and discuss how it may contribute to circuit function.http://dx.doi.org/10.1155/2011/254724 |
| spellingShingle | Arianna Maffei The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses Neural Plasticity |
| title | The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses |
| title_full | The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses |
| title_fullStr | The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses |
| title_full_unstemmed | The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses |
| title_short | The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses |
| title_sort | many forms and functions of long term plasticity at gabaergic synapses |
| url | http://dx.doi.org/10.1155/2011/254724 |
| work_keys_str_mv | AT ariannamaffei themanyformsandfunctionsoflongtermplasticityatgabaergicsynapses AT ariannamaffei manyformsandfunctionsoflongtermplasticityatgabaergicsynapses |