Parathyroid hormone, cognitive function and dementia: a systematic review.
<h4>Background</h4>Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling...
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127574&type=printable |
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| author | Ilianna Lourida Jo Thompson-Coon Chris M Dickens Maya Soni Elżbieta Kuźma Katarina Kos David J Llewellyn |
| author_facet | Ilianna Lourida Jo Thompson-Coon Chris M Dickens Maya Soni Elżbieta Kuźma Katarina Kos David J Llewellyn |
| author_sort | Ilianna Lourida |
| collection | DOAJ |
| description | <h4>Background</h4>Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling. Some studies support a significant link between PTH levels and dementia whereas others do not.<h4>Methods</h4>We conducted a systematic review through January 2014 to evaluate the association between PTH and parathyroid conditions, cognitive function and dementia. Eleven electronic databases and citation indexes were searched including Medline, Embase and the Cochrane Library. Hand searches of selected journals, reference lists of primary studies and reviews were also conducted along with websites of key organizations. Two reviewers independently screened titles and abstracts of identified studies. Data extraction and study quality were performed by one and checked by a second reviewer using predefined criteria. A narrative synthesis was performed due to the heterogeneity of included studies.<h4>Results</h4>The twenty-seven studies identified were of low and moderate quality, and challenging to synthesize due to inadequate reporting. Findings from six observational studies were mixed but suggest a link between higher serum PTH levels and increased odds of poor cognition or dementia. Two case-control studies of hypoparathyroidism provide limited evidence for a link with poorer cognitive function. Thirteen pre-post surgery studies for primary hyperparathyroidism show mixed evidence for improvements in memory though limited agreement in other cognitive domains. There was some degree of cognitive impairment and improvement postoperatively in observational studies of secondary hyperparathyroidism but no evident pattern of associations with specific cognitive domains.<h4>Conclusions</h4>Mixed evidence offers weak support for a link between PTH, cognition and dementia due to the paucity of high quality research in this area. |
| format | Article |
| id | doaj-art-4ecb1b2ed5354c1d97ecf86d71fc2bbf |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4ecb1b2ed5354c1d97ecf86d71fc2bbf2025-08-20T02:37:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012757410.1371/journal.pone.0127574Parathyroid hormone, cognitive function and dementia: a systematic review.Ilianna LouridaJo Thompson-CoonChris M DickensMaya SoniElżbieta KuźmaKatarina KosDavid J Llewellyn<h4>Background</h4>Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling. Some studies support a significant link between PTH levels and dementia whereas others do not.<h4>Methods</h4>We conducted a systematic review through January 2014 to evaluate the association between PTH and parathyroid conditions, cognitive function and dementia. Eleven electronic databases and citation indexes were searched including Medline, Embase and the Cochrane Library. Hand searches of selected journals, reference lists of primary studies and reviews were also conducted along with websites of key organizations. Two reviewers independently screened titles and abstracts of identified studies. Data extraction and study quality were performed by one and checked by a second reviewer using predefined criteria. A narrative synthesis was performed due to the heterogeneity of included studies.<h4>Results</h4>The twenty-seven studies identified were of low and moderate quality, and challenging to synthesize due to inadequate reporting. Findings from six observational studies were mixed but suggest a link between higher serum PTH levels and increased odds of poor cognition or dementia. Two case-control studies of hypoparathyroidism provide limited evidence for a link with poorer cognitive function. Thirteen pre-post surgery studies for primary hyperparathyroidism show mixed evidence for improvements in memory though limited agreement in other cognitive domains. There was some degree of cognitive impairment and improvement postoperatively in observational studies of secondary hyperparathyroidism but no evident pattern of associations with specific cognitive domains.<h4>Conclusions</h4>Mixed evidence offers weak support for a link between PTH, cognition and dementia due to the paucity of high quality research in this area.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127574&type=printable |
| spellingShingle | Ilianna Lourida Jo Thompson-Coon Chris M Dickens Maya Soni Elżbieta Kuźma Katarina Kos David J Llewellyn Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS ONE |
| title | Parathyroid hormone, cognitive function and dementia: a systematic review. |
| title_full | Parathyroid hormone, cognitive function and dementia: a systematic review. |
| title_fullStr | Parathyroid hormone, cognitive function and dementia: a systematic review. |
| title_full_unstemmed | Parathyroid hormone, cognitive function and dementia: a systematic review. |
| title_short | Parathyroid hormone, cognitive function and dementia: a systematic review. |
| title_sort | parathyroid hormone cognitive function and dementia a systematic review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127574&type=printable |
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