Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review
Cancer remains one of the foremost causes of death worldwide. Despite advancements in pharmaceutical therapies, patients continue to experience adverse effects. Consequently, there is a considerable interest in exploring mushrooms as a supplemental cancer treatment. In Asian countries, edible and me...
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| Format: | Article |
| Language: | English |
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AIMS Press
2025-03-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2025005 |
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| author | Madhurima Roy Chandana Paul Nilasish Pal Tanima Saha Nirmalendu Das |
| author_facet | Madhurima Roy Chandana Paul Nilasish Pal Tanima Saha Nirmalendu Das |
| author_sort | Madhurima Roy |
| collection | DOAJ |
| description | Cancer remains one of the foremost causes of death worldwide. Despite advancements in pharmaceutical therapies, patients continue to experience adverse effects. Consequently, there is a considerable interest in exploring mushrooms as a supplemental cancer treatment. In Asian countries, edible and medicinal mushrooms have long been consumed in both culinary practices and herbal remedies. Their health and nutritional benefits have also garnered rising attention in Europe. Food-grade mushrooms have a variety of pharmacological properties, including soothing and immunomodulating effects, and are associated with abundant therapeutic benefits. The primary mechanisms behind their anticancer activity comprise immune system improvement, cell cycle arrest, regulation of apoptosis, prevention of metastasis, and inhibition of cancer cell growth. Here, we thoroughly review the anticancer activities of several culinary and medicinal mushrooms, as well as some endophytic fungi, with a particular focus on potential bioactive compounds and their molecular mechanisms. |
| format | Article |
| id | doaj-art-4ecae483b0c74de79cab64eb9cd43ee8 |
| institution | Kabale University |
| issn | 2372-0301 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj-art-4ecae483b0c74de79cab64eb9cd43ee82025-08-20T03:48:19ZengAIMS PressAIMS Molecular Science2372-03012025-03-01121679810.3934/molsci.2025005Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive reviewMadhurima Roy0Chandana Paul1Nilasish Pal2Tanima Saha3Nirmalendu Das4Department of Botany, Acharya Prafulla Chandra College, New Barrackpore, Kolkata 700131, W.B., IndiaDepartment of Microbiology, St. Xavier's College (Autonomous), Kolkata 700016, W.B., IndiaDepartment of Chemistry, Seth Anandaram Jaipuria College, Kolkata700005, W.B., IndiaDepartment of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, Nadia, W.B., IndiaDepartment of Botany, Barasat Government College, Barasat, Kolkata 700124, W.B., IndiaCancer remains one of the foremost causes of death worldwide. Despite advancements in pharmaceutical therapies, patients continue to experience adverse effects. Consequently, there is a considerable interest in exploring mushrooms as a supplemental cancer treatment. In Asian countries, edible and medicinal mushrooms have long been consumed in both culinary practices and herbal remedies. Their health and nutritional benefits have also garnered rising attention in Europe. Food-grade mushrooms have a variety of pharmacological properties, including soothing and immunomodulating effects, and are associated with abundant therapeutic benefits. The primary mechanisms behind their anticancer activity comprise immune system improvement, cell cycle arrest, regulation of apoptosis, prevention of metastasis, and inhibition of cancer cell growth. Here, we thoroughly review the anticancer activities of several culinary and medicinal mushrooms, as well as some endophytic fungi, with a particular focus on potential bioactive compounds and their molecular mechanisms.https://www.aimspress.com/article/doi/10.3934/molsci.2025005anticancer compoundantitumorendophytic fungicytotoxicityimmunomodulatorymushroomnutraceuticalssecondary metabolites |
| spellingShingle | Madhurima Roy Chandana Paul Nilasish Pal Tanima Saha Nirmalendu Das Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review AIMS Molecular Science anticancer compound antitumor endophytic fungi cytotoxicity immunomodulatory mushroom nutraceuticals secondary metabolites |
| title | Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review |
| title_full | Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review |
| title_fullStr | Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review |
| title_full_unstemmed | Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review |
| title_short | Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review |
| title_sort | pharmacological and therapeutic inventory of fungi in cancertherapy a comprehensive review |
| topic | anticancer compound antitumor endophytic fungi cytotoxicity immunomodulatory mushroom nutraceuticals secondary metabolites |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2025005 |
| work_keys_str_mv | AT madhurimaroy pharmacologicalandtherapeuticinventoryoffungiincancertherapyacomprehensivereview AT chandanapaul pharmacologicalandtherapeuticinventoryoffungiincancertherapyacomprehensivereview AT nilasishpal pharmacologicalandtherapeuticinventoryoffungiincancertherapyacomprehensivereview AT tanimasaha pharmacologicalandtherapeuticinventoryoffungiincancertherapyacomprehensivereview AT nirmalendudas pharmacologicalandtherapeuticinventoryoffungiincancertherapyacomprehensivereview |