An in-frame deletion mutation in MLH1 drives Lynch syndrome-associated colorectal cancer

An in-frame deletion mutation in MLH1 drives Lynch syndrome-associated colorectal cancer

Abstract Lynch syndrome (LS) is the most common inherited disorder predisposing individuals to colorectal cancer (CRC). It results from germline defects in DNA mismatch repair (MMR) genes, which are critical for maintaining genomic integrity. Here, we demonstrate that the expression of the MMR genes...

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Bibliographic Details
Main Authors: Xiaojuan Lin, Ce Bian, Dongni Liang, Lin Li, Qingqing Tang, Qingli Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
In-frame deletion mutation
MLH1
Lynch syndrome
Colorectal cancer
Online Access:https://doi.org/10.1186/s12885-025-14554-6
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