Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study
Background: Major nosocomial infections in intensive care units (ICUs) that significantly increase morbidity, and lengthen hospital stays, and death are ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT). Aim: This study evaluated the bacterial profile and antibi...
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Zagazig University, Faculty of Medicine
2025-08-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_428018_d30e6619bf62933f0660467bf7ad0642.pdf |
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| author | Reham Raafat Hamed Hoda Abdel-Hamid Nahla Sahloul |
| author_facet | Reham Raafat Hamed Hoda Abdel-Hamid Nahla Sahloul |
| author_sort | Reham Raafat Hamed |
| collection | DOAJ |
| description | Background: Major nosocomial infections in intensive care units (ICUs) that significantly increase morbidity, and lengthen hospital stays, and death are ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT). Aim: This study evaluated the bacterial profile and antibiotic resistance patterns in endotracheal aspirates collected from 96 mechanically ventilated patients at Kasr Al-Ainy Hospital, Cairo University. Methods: This is a cross-sectional study of a12 month duration including data from culture-proven VAP OR VAT patients admitted at the ICU, in Cairo University Hospital. Results: Out of 96 endotracheal aspirate samples, 73 (76%) were culture positive. Of these positive cultures, 46.9% demonstrated monomicrobial growth, while 29.2% were polymicrobial. The findings of testing for antibiotic susceptibility and microbiological cultures showed that multidrug-resistant organisms (MDROs) were highly prevalent, especially in Gram-negative bacteria. Notably, 3.5% of cases had extended-spectrum β-lactamase (ESBL) synthesis, while 45.3% of isolates had carbapenem resistance. Conclusions: our research offers vital epidemiological information that can help drive the creation of focused interventions and clinical decision-making to lessen the risk of antibiotic resistance in critical care settings. To guarantee efficient management of VAP/VAT and to enhance patient survival in the face of growing antibiotic resistance, these approaches must be included in standard clinical practice. Also highlights how urgently strong antimicrobial stewardship initiatives and focused infection control (IC) strategies are needed to direct empirical treatment for patients in critical condition. |
| format | Article |
| id | doaj-art-4ec4530221df47fc917dbe27db2935f5 |
| institution | Kabale University |
| issn | 2682-4132 2682-4140 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj-art-4ec4530221df47fc917dbe27db2935f52025-08-20T03:37:23ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402025-08-01635093600110.21608/mid.2025.367446.2618428018Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional studyReham Raafat Hamed0Hoda Abdel-Hamid1Nahla Sahloul2Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, EgyptChest diseases Department, Faculty of Medicine, Cairo University, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, EgyptBackground: Major nosocomial infections in intensive care units (ICUs) that significantly increase morbidity, and lengthen hospital stays, and death are ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT). Aim: This study evaluated the bacterial profile and antibiotic resistance patterns in endotracheal aspirates collected from 96 mechanically ventilated patients at Kasr Al-Ainy Hospital, Cairo University. Methods: This is a cross-sectional study of a12 month duration including data from culture-proven VAP OR VAT patients admitted at the ICU, in Cairo University Hospital. Results: Out of 96 endotracheal aspirate samples, 73 (76%) were culture positive. Of these positive cultures, 46.9% demonstrated monomicrobial growth, while 29.2% were polymicrobial. The findings of testing for antibiotic susceptibility and microbiological cultures showed that multidrug-resistant organisms (MDROs) were highly prevalent, especially in Gram-negative bacteria. Notably, 3.5% of cases had extended-spectrum β-lactamase (ESBL) synthesis, while 45.3% of isolates had carbapenem resistance. Conclusions: our research offers vital epidemiological information that can help drive the creation of focused interventions and clinical decision-making to lessen the risk of antibiotic resistance in critical care settings. To guarantee efficient management of VAP/VAT and to enhance patient survival in the face of growing antibiotic resistance, these approaches must be included in standard clinical practice. Also highlights how urgently strong antimicrobial stewardship initiatives and focused infection control (IC) strategies are needed to direct empirical treatment for patients in critical condition.https://mid.journals.ekb.eg/article_428018_d30e6619bf62933f0660467bf7ad0642.pdfcarbapenem resistancemultidrug-resistant organisms (mdros)ventilator-associated pneumonia (vap)ventilator-associated tracheobronchitis (vat) |
| spellingShingle | Reham Raafat Hamed Hoda Abdel-Hamid Nahla Sahloul Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study Microbes and Infectious Diseases carbapenem resistance multidrug-resistant organisms (mdros) ventilator-associated pneumonia (vap) ventilator-associated tracheobronchitis (vat) |
| title | Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study |
| title_full | Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study |
| title_fullStr | Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study |
| title_full_unstemmed | Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study |
| title_short | Antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients: A cross-sectional study |
| title_sort | antibiotic resistance patterns in endotracheal aspirates of mechanically ventilated patients a cross sectional study |
| topic | carbapenem resistance multidrug-resistant organisms (mdros) ventilator-associated pneumonia (vap) ventilator-associated tracheobronchitis (vat) |
| url | https://mid.journals.ekb.eg/article_428018_d30e6619bf62933f0660467bf7ad0642.pdf |
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