Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus

Abstract Exposure to novel environments (NE) induces structural and functional changes in multiple brain areas, including the hippocampus, driven in part by changes in gene expression. However, the cell-type-specific transcriptional and chromatin responses to NE remain poorly understood. We employed...

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Bibliographic Details
Main Authors: Lisa Traunmüller, Erin E. Duffy, Hanqing Liu, Stella Sanalidou, Sebastian Krüttner, Elena G. Assad, Senmiao Sun, Naeem S. Pajarillo, Nancy Niu, Eric C. Griffith, Michael E. Greenberg
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63029-6
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