Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is curr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/8844963 |
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| author | Vijaya Nath Mishra Nidhi Kumari Abhishek Pathak Rajnish Kumar Chaturvedi Arun Kumar Gupta Rameshwar Nath Chaurasia |
| author_facet | Vijaya Nath Mishra Nidhi Kumari Abhishek Pathak Rajnish Kumar Chaturvedi Arun Kumar Gupta Rameshwar Nath Chaurasia |
| author_sort | Vijaya Nath Mishra |
| collection | DOAJ |
| description | An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. The slow translational progress in the field of research suggests that a large number of studies are urgently required. In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially concerning phage therapy (PT). Bacteriophages are viruses that infect and kill bacterial cells. Several studies have confirmed that in addition to their antibacterial abilities, bacteriophages also show antiviral and antifungal properties. It has also been shown that PT is effective for building immunity against viral pathogens by reducing the activation of NF kappa B; additionally, phages produce the antiviral protein phagicin. The Ganges river in India, which originates from the Himalayan range, is known to harbor a large number of bacteriophages, which are released into the river gradually by the melting permafrost. Water from this river has traditionally been considered a therapeutic agent for several diseases. In this review, we hypothesize that the Ganges river may play a therapeutic role in the treatment of COVID-19. |
| format | Article |
| id | doaj-art-4ec1273c193e48d8aec7ebca82f2cb59 |
| institution | OA Journals |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-4ec1273c193e48d8aec7ebca82f2cb592025-08-20T02:05:35ZengWileyInternational Journal of Microbiology1687-918X1687-91982020-01-01202010.1155/2020/88449638844963Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 InfectionVijaya Nath Mishra0Nidhi Kumari1Abhishek Pathak2Rajnish Kumar Chaturvedi3Arun Kumar Gupta4Rameshwar Nath Chaurasia5Department of Neurology, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Neurology, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Neurology, Banaras Hindu University, Varanasi 221005, IndiaDevelopmental Toxicology Laboratory, System Toxicology and Health Risk Assesment Group, Vishvigyan Bhawan, 31 MG Marg, Lucknow, UP 226001, IndiaAllahabad High Court, Allahabad 211001, IndiaDepartment of Neurology, Banaras Hindu University, Varanasi 221005, IndiaAn outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. The slow translational progress in the field of research suggests that a large number of studies are urgently required. In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially concerning phage therapy (PT). Bacteriophages are viruses that infect and kill bacterial cells. Several studies have confirmed that in addition to their antibacterial abilities, bacteriophages also show antiviral and antifungal properties. It has also been shown that PT is effective for building immunity against viral pathogens by reducing the activation of NF kappa B; additionally, phages produce the antiviral protein phagicin. The Ganges river in India, which originates from the Himalayan range, is known to harbor a large number of bacteriophages, which are released into the river gradually by the melting permafrost. Water from this river has traditionally been considered a therapeutic agent for several diseases. In this review, we hypothesize that the Ganges river may play a therapeutic role in the treatment of COVID-19.http://dx.doi.org/10.1155/2020/8844963 |
| spellingShingle | Vijaya Nath Mishra Nidhi Kumari Abhishek Pathak Rajnish Kumar Chaturvedi Arun Kumar Gupta Rameshwar Nath Chaurasia Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection International Journal of Microbiology |
| title | Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
| title_full | Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
| title_fullStr | Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
| title_full_unstemmed | Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
| title_short | Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
| title_sort | possible role for bacteriophages in the treatment of sars cov 2 infection |
| url | http://dx.doi.org/10.1155/2020/8844963 |
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