A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain
Rosaria Lanzisera,1 Fabrizio Gervasoni,2 Maria Sole Rossato,3 Germano Tarantino,3 Antonella Lo Mauro,4 Elisabetta Geri1 1UOC Recupero E Riabilitazione Funzionale, Ambito Territoriale Pisano, ASL Toscana Nordovest, Pisa, Italy; 2ASST Fatebenefratelli Sacco, Milan, Italy; 3PharmaNutra S.p.A., Pisa, It...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-05-01
|
| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-real-world-study-of-cetylated-fatty-acids-food-supplement-administra-peer-reviewed-fulltext-article-JPR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849433618527551488 |
|---|---|
| author | Lanzisera R Gervasoni F Rossato MS Tarantino G Lo Mauro A Geri E |
| author_facet | Lanzisera R Gervasoni F Rossato MS Tarantino G Lo Mauro A Geri E |
| author_sort | Lanzisera R |
| collection | DOAJ |
| description | Rosaria Lanzisera,1 Fabrizio Gervasoni,2 Maria Sole Rossato,3 Germano Tarantino,3 Antonella Lo Mauro,4 Elisabetta Geri1 1UOC Recupero E Riabilitazione Funzionale, Ambito Territoriale Pisano, ASL Toscana Nordovest, Pisa, Italy; 2ASST Fatebenefratelli Sacco, Milan, Italy; 3PharmaNutra S.p.A., Pisa, Italy; 4Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, ItalyCorrespondence: Maria Sole Rossato, Email ms.rossato@pharmanutra.itPurpose: This real-world observational study was conducted to evaluate decrease in pain after 30-day administration of a new oral cetylated fatty acids (CFA) food supplement, assess if decreased pain resulted in a lower consumption of oral non-steroidal anti-inflammatory drugs (NSAIDs), and improvement in related gastric side effects. It was the first study of this food supplement in a real-world setting.Patients and Methods: A hundred and twenty Italian primary care physicians recruited 562 patients who were prescribed oral CFA. Patients completed the Brief Pain Inventory (BPI) questionnaire at baseline and after 30 days of dosing. Their CFA intake adherence and use of NSAIDs were recorded. All analyses were done using R statistical software; p-value ≤ 0.005 was considered statistically significant.Results: We analyzed data of 196 males and 366 females aged in an average 49.2 years. After 30 days of CFA intake, we observed a statistically significant reduction (38.84%) in the overall pain score, 44.53% reduction in the interference score in daily activities, relief from pain within the previous 24 hours 47.16 (± 11.44%) at baseline and 62.14 (± 27.93%) after 30 days, and progressive reduction in NSAID intake frequency and total dose over time. More than half of participants (55.2%) reported improvement in gastric side effects typically associated with NSAID use.Conclusion: Data analyses indicated that using the new oral CFA food supplement decreased pain, which helped improve the quality of life, better perform daily activities (interference reduced by 44.5%), and reduce painkiller consumption by 19.7% in terms of both dose and frequency. Half of participants (55.2%) rated NSAID-related hyperchlorhydria and heartburn as improved. Although placebo effect might have contributed, the results suggest that CFA may have a positive effect in patients with sub-acute and chronic musculoskeletal pain and can enhance therapies typically used in this population.Keywords: pain, cetylated fatty acids, quality of life |
| format | Article |
| id | doaj-art-4ebd93d129f84c69b3546feb6e86d0f1 |
| institution | Kabale University |
| issn | 1178-7090 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj-art-4ebd93d129f84c69b3546feb6e86d0f12025-08-20T03:26:57ZengDove Medical PressJournal of Pain Research1178-70902025-05-01Volume 18Issue 127512760103434A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal PainLanzisera RGervasoni FRossato MSTarantino G0Lo Mauro AGeri EScientificRosaria Lanzisera,1 Fabrizio Gervasoni,2 Maria Sole Rossato,3 Germano Tarantino,3 Antonella Lo Mauro,4 Elisabetta Geri1 1UOC Recupero E Riabilitazione Funzionale, Ambito Territoriale Pisano, ASL Toscana Nordovest, Pisa, Italy; 2ASST Fatebenefratelli Sacco, Milan, Italy; 3PharmaNutra S.p.A., Pisa, Italy; 4Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, ItalyCorrespondence: Maria Sole Rossato, Email ms.rossato@pharmanutra.itPurpose: This real-world observational study was conducted to evaluate decrease in pain after 30-day administration of a new oral cetylated fatty acids (CFA) food supplement, assess if decreased pain resulted in a lower consumption of oral non-steroidal anti-inflammatory drugs (NSAIDs), and improvement in related gastric side effects. It was the first study of this food supplement in a real-world setting.Patients and Methods: A hundred and twenty Italian primary care physicians recruited 562 patients who were prescribed oral CFA. Patients completed the Brief Pain Inventory (BPI) questionnaire at baseline and after 30 days of dosing. Their CFA intake adherence and use of NSAIDs were recorded. All analyses were done using R statistical software; p-value ≤ 0.005 was considered statistically significant.Results: We analyzed data of 196 males and 366 females aged in an average 49.2 years. After 30 days of CFA intake, we observed a statistically significant reduction (38.84%) in the overall pain score, 44.53% reduction in the interference score in daily activities, relief from pain within the previous 24 hours 47.16 (± 11.44%) at baseline and 62.14 (± 27.93%) after 30 days, and progressive reduction in NSAID intake frequency and total dose over time. More than half of participants (55.2%) reported improvement in gastric side effects typically associated with NSAID use.Conclusion: Data analyses indicated that using the new oral CFA food supplement decreased pain, which helped improve the quality of life, better perform daily activities (interference reduced by 44.5%), and reduce painkiller consumption by 19.7% in terms of both dose and frequency. Half of participants (55.2%) rated NSAID-related hyperchlorhydria and heartburn as improved. Although placebo effect might have contributed, the results suggest that CFA may have a positive effect in patients with sub-acute and chronic musculoskeletal pain and can enhance therapies typically used in this population.Keywords: pain, cetylated fatty acids, quality of lifehttps://www.dovepress.com/a-real-world-study-of-cetylated-fatty-acids-food-supplement-administra-peer-reviewed-fulltext-article-JPRpaincetylated fatty acidsquality of life |
| spellingShingle | Lanzisera R Gervasoni F Rossato MS Tarantino G Lo Mauro A Geri E A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain Journal of Pain Research pain cetylated fatty acids quality of life |
| title | A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain |
| title_full | A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain |
| title_fullStr | A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain |
| title_full_unstemmed | A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain |
| title_short | A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain |
| title_sort | real world study of cetylated fatty acids food supplement administration in italian adults for sub acute or chronic musculoskeletal pain |
| topic | pain cetylated fatty acids quality of life |
| url | https://www.dovepress.com/a-real-world-study-of-cetylated-fatty-acids-food-supplement-administra-peer-reviewed-fulltext-article-JPR |
| work_keys_str_mv | AT lanziserar arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT gervasonif arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT rossatoms arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT tarantinog arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT lomauroa arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT gerie arealworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT lanziserar realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT gervasonif realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT rossatoms realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT tarantinog realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT lomauroa realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain AT gerie realworldstudyofcetylatedfattyacidsfoodsupplementadministrationinitalianadultsforsubacuteorchronicmusculoskeletalpain |