Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome
Catastrophic antiphospholipid syndrome is a rare condition with high morbidity and mortality. We present a refractory case of catastrophic antiphospholipid syndrome with a view to highlight the importance of early identification and aggressive treatment of this condition. A 36-year-old female presen...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/1041396 |
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| _version_ | 1832552077837991936 |
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| author | Karthik Nath Andrew McCann |
| author_facet | Karthik Nath Andrew McCann |
| author_sort | Karthik Nath |
| collection | DOAJ |
| description | Catastrophic antiphospholipid syndrome is a rare condition with high morbidity and mortality. We present a refractory case of catastrophic antiphospholipid syndrome with a view to highlight the importance of early identification and aggressive treatment of this condition. A 36-year-old female presented with clinical manifestations of multiorgan vascular occlusion with a known history of primary antiphospholipid syndrome. The presentation was on a background of a recent change of her long-term anticoagulation from warfarin to therapeutic low-molecular-weight heparin. Given that multiorgan involvement with 3 organ systems occurred nearly simultaneously, a diagnosis of probable catastrophic antiphospholipid syndrome was made. Prompt therapeutic anticoagulation, antiplatelet, and glucocorticoid therapy was commenced. Despite this, the patient continued to demonstrate clinical features concerning for ongoing small vessel occlusion necessitating aggressive immunomodulatory therapy in the form of intravenous immunoglobulin, plasma exchange, and rituximab. |
| format | Article |
| id | doaj-art-4eb8f025ccc741069ba0567751db9067 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4eb8f025ccc741069ba0567751db90672025-02-03T05:59:35ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/10413961041396Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid SyndromeKarthik Nath0Andrew McCann1Department of Haematology and Bone Marrow Transplantation, Townsville Hospital, Douglas, QLD, AustraliaDepartment of Vascular Medicine, Princess Alexandra Hospital, Brisbane, QLD, AustraliaCatastrophic antiphospholipid syndrome is a rare condition with high morbidity and mortality. We present a refractory case of catastrophic antiphospholipid syndrome with a view to highlight the importance of early identification and aggressive treatment of this condition. A 36-year-old female presented with clinical manifestations of multiorgan vascular occlusion with a known history of primary antiphospholipid syndrome. The presentation was on a background of a recent change of her long-term anticoagulation from warfarin to therapeutic low-molecular-weight heparin. Given that multiorgan involvement with 3 organ systems occurred nearly simultaneously, a diagnosis of probable catastrophic antiphospholipid syndrome was made. Prompt therapeutic anticoagulation, antiplatelet, and glucocorticoid therapy was commenced. Despite this, the patient continued to demonstrate clinical features concerning for ongoing small vessel occlusion necessitating aggressive immunomodulatory therapy in the form of intravenous immunoglobulin, plasma exchange, and rituximab.http://dx.doi.org/10.1155/2018/1041396 |
| spellingShingle | Karthik Nath Andrew McCann Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome Case Reports in Hematology |
| title | Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome |
| title_full | Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome |
| title_fullStr | Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome |
| title_full_unstemmed | Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome |
| title_short | Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome |
| title_sort | immunomodulation in the treatment of refractory catastrophic antiphospholipid syndrome |
| url | http://dx.doi.org/10.1155/2018/1041396 |
| work_keys_str_mv | AT karthiknath immunomodulationinthetreatmentofrefractorycatastrophicantiphospholipidsyndrome AT andrewmccann immunomodulationinthetreatmentofrefractorycatastrophicantiphospholipidsyndrome |