Individualized prediction of future cognition based on developmental changes in cortical anatomy

Predictive modeling studies have started to reveal brain measures underlying cognition; however, most studies are based on cross-sectional data (brain measures acquired at one time point). Since brain development comprises of continuously ongoing events leading to cognitive development, predictive m...

Full description

Saved in:
Bibliographic Details
Main Authors: Budhachandra Khundrakpam, Linda Booij, Seun Jeon, Sherif Karama, Jussi Tohka, Alan C. Evans
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:NeuroImage: Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2666956022000514
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850045757926670336
author Budhachandra Khundrakpam
Linda Booij
Seun Jeon
Sherif Karama
Jussi Tohka
Alan C. Evans
author_facet Budhachandra Khundrakpam
Linda Booij
Seun Jeon
Sherif Karama
Jussi Tohka
Alan C. Evans
author_sort Budhachandra Khundrakpam
collection DOAJ
description Predictive modeling studies have started to reveal brain measures underlying cognition; however, most studies are based on cross-sectional data (brain measures acquired at one time point). Since brain development comprises of continuously ongoing events leading to cognitive development, predictive modeling studies need to consider ‘longitudinal brain change’ as opposed to ‘cross-sectional brain measures’. Using longitudinal neuroimaging and cognitive data (global executive composite score, an index of executive function) from 82 individuals (aged 5–14 years, scanned 3 times), we built highly accurate prediction models (r = 0.61, p = 1.6e-09) of future cognition (assessed at visit 3) based on developmental changes in cortical anatomy (from visit 1 to 2). More importantly, longitudinal brain change (i.e. change in cortical anatomy from visit 1 to 2) and cross-sectional brain measures (cortical anatomy at visit 1 and 2) were critical for predicting future cognition, suggesting the need for considering longitudinal brain change in predicting cognitive outcomes.
format Article
id doaj-art-4eb1f6cb503f45f1878e52013692b2a4
institution DOAJ
issn 2666-9560
language English
publishDate 2022-12-01
publisher Elsevier
record_format Article
series NeuroImage: Reports
spelling doaj-art-4eb1f6cb503f45f1878e52013692b2a42025-08-20T02:54:37ZengElsevierNeuroImage: Reports2666-95602022-12-012410012710.1016/j.ynirp.2022.100127Individualized prediction of future cognition based on developmental changes in cortical anatomyBudhachandra Khundrakpam0Linda Booij1Seun Jeon2Sherif Karama3Jussi Tohka4Alan C. Evans5McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, H3A 2B4, Canada; Corresponding author. Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B42, Canada.Department of Psychology, Concordia University, Montreal, QC, H4B 1R6, Canada; CHU Sainte-Justine Hospital Research Centre, Montreal, QC, H3T 1C5, CanadaMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, H3A 2B4, CanadaDouglas Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H 1R3, CanadaUniversity of Eastern Finland, CanadaMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, H3A 2B4, CanadaPredictive modeling studies have started to reveal brain measures underlying cognition; however, most studies are based on cross-sectional data (brain measures acquired at one time point). Since brain development comprises of continuously ongoing events leading to cognitive development, predictive modeling studies need to consider ‘longitudinal brain change’ as opposed to ‘cross-sectional brain measures’. Using longitudinal neuroimaging and cognitive data (global executive composite score, an index of executive function) from 82 individuals (aged 5–14 years, scanned 3 times), we built highly accurate prediction models (r = 0.61, p = 1.6e-09) of future cognition (assessed at visit 3) based on developmental changes in cortical anatomy (from visit 1 to 2). More importantly, longitudinal brain change (i.e. change in cortical anatomy from visit 1 to 2) and cross-sectional brain measures (cortical anatomy at visit 1 and 2) were critical for predicting future cognition, suggesting the need for considering longitudinal brain change in predicting cognitive outcomes.http://www.sciencedirect.com/science/article/pii/S2666956022000514
spellingShingle Budhachandra Khundrakpam
Linda Booij
Seun Jeon
Sherif Karama
Jussi Tohka
Alan C. Evans
Individualized prediction of future cognition based on developmental changes in cortical anatomy
NeuroImage: Reports
title Individualized prediction of future cognition based on developmental changes in cortical anatomy
title_full Individualized prediction of future cognition based on developmental changes in cortical anatomy
title_fullStr Individualized prediction of future cognition based on developmental changes in cortical anatomy
title_full_unstemmed Individualized prediction of future cognition based on developmental changes in cortical anatomy
title_short Individualized prediction of future cognition based on developmental changes in cortical anatomy
title_sort individualized prediction of future cognition based on developmental changes in cortical anatomy
url http://www.sciencedirect.com/science/article/pii/S2666956022000514
work_keys_str_mv AT budhachandrakhundrakpam individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy
AT lindabooij individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy
AT seunjeon individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy
AT sherifkarama individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy
AT jussitohka individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy
AT alancevans individualizedpredictionoffuturecognitionbasedondevelopmentalchangesincorticalanatomy