Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study
Background: Intraoperative hemodynamic management is critical for optimizing graft function in kidney transplantation. The study aimed to investigate the association between intraoperative mean arterial pressure (MAP) and central venous pressure (CVP) with early graft function, as measured by postop...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Bali Journal of Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.4103/bjoa.bjoa_76_25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414177058193408 |
|---|---|
| author | Juni Kurniawaty Novita Intan Arovah |
| author_facet | Juni Kurniawaty Novita Intan Arovah |
| author_sort | Juni Kurniawaty |
| collection | DOAJ |
| description | Background: Intraoperative hemodynamic management is critical for optimizing graft function in kidney transplantation. The study aimed to investigate the association between intraoperative mean arterial pressure (MAP) and central venous pressure (CVP) with early graft function, as measured by postoperative serum creatinine levels, in patients undergoing living donor kidney transplantation. Materials and Methods: This retrospective study included 65 adult patients who underwent living donor renal transplantation. Serum creatinine levels were measured preoperatively and on postoperative days 1, 2, and 3. Repeated measures ANOVA was used to evaluate changes in creatinine levels over time and to assess the impact of MAP and CVP. Linear regression was used to identify predictors of postoperative creatinine levels. Results: The mean age of participants was 39.28 ± 12.83 years. A significant reduction (P < 0.001) in serum creatinine was observed from the preoperative period to each postoperative day, with no significant differences between postoperative days. Repeated measures ANOVA confirmed significant within-subject variation in creatinine levels (F = 26.74, P < 0.001). However, MAP (P = 0.730), CVP (P = 0.225), and their interaction (P = 0.628) were not significantly associated with changes in creatinine levels. On multivariable analysis, female sex was significantly associated with higher creatinine levels on days 1 and 3 (P = 0.035 and P = 0.049, respectively), and older age was associated with lower creatinine on day 3 (P = 0.010). Conclusion: In this cohort, early postoperative renal function improved significantly but was not associated with intraoperative MAP or CVP. These findings suggest that traditional hemodynamic targets may not reliably predict early graft function, and further research should explore alternative perioperative predictors. |
| format | Article |
| id | doaj-art-4eb1a38dcccb4ebc9e78ecf80783f1e9 |
| institution | Kabale University |
| issn | 2549-2276 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Bali Journal of Anesthesiology |
| spelling | doaj-art-4eb1a38dcccb4ebc9e78ecf80783f1e92025-08-20T03:33:54ZengWolters Kluwer Medknow PublicationsBali Journal of Anesthesiology2549-22762025-04-0192758110.4103/bjoa.bjoa_76_25Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective StudyJuni KurniawatyNovita Intan ArovahBackground: Intraoperative hemodynamic management is critical for optimizing graft function in kidney transplantation. The study aimed to investigate the association between intraoperative mean arterial pressure (MAP) and central venous pressure (CVP) with early graft function, as measured by postoperative serum creatinine levels, in patients undergoing living donor kidney transplantation. Materials and Methods: This retrospective study included 65 adult patients who underwent living donor renal transplantation. Serum creatinine levels were measured preoperatively and on postoperative days 1, 2, and 3. Repeated measures ANOVA was used to evaluate changes in creatinine levels over time and to assess the impact of MAP and CVP. Linear regression was used to identify predictors of postoperative creatinine levels. Results: The mean age of participants was 39.28 ± 12.83 years. A significant reduction (P < 0.001) in serum creatinine was observed from the preoperative period to each postoperative day, with no significant differences between postoperative days. Repeated measures ANOVA confirmed significant within-subject variation in creatinine levels (F = 26.74, P < 0.001). However, MAP (P = 0.730), CVP (P = 0.225), and their interaction (P = 0.628) were not significantly associated with changes in creatinine levels. On multivariable analysis, female sex was significantly associated with higher creatinine levels on days 1 and 3 (P = 0.035 and P = 0.049, respectively), and older age was associated with lower creatinine on day 3 (P = 0.010). Conclusion: In this cohort, early postoperative renal function improved significantly but was not associated with intraoperative MAP or CVP. These findings suggest that traditional hemodynamic targets may not reliably predict early graft function, and further research should explore alternative perioperative predictors.https://doi.org/10.4103/bjoa.bjoa_76_25central venous pressurecreatinineearly postoperative outcomesgraft functionhemodynamicsliving donormean arterial pressurerenal transplantation |
| spellingShingle | Juni Kurniawaty Novita Intan Arovah Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study Bali Journal of Anesthesiology central venous pressure creatinine early postoperative outcomes graft function hemodynamics living donor mean arterial pressure renal transplantation |
| title | Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study |
| title_full | Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study |
| title_fullStr | Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study |
| title_full_unstemmed | Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study |
| title_short | Association of Intraoperative Hemodynamic Parameters and Creatinine Levels with Early Graft Function Following Living Donor Kidney Transplantation: A Retrospective Study |
| title_sort | association of intraoperative hemodynamic parameters and creatinine levels with early graft function following living donor kidney transplantation a retrospective study |
| topic | central venous pressure creatinine early postoperative outcomes graft function hemodynamics living donor mean arterial pressure renal transplantation |
| url | https://doi.org/10.4103/bjoa.bjoa_76_25 |
| work_keys_str_mv | AT junikurniawaty associationofintraoperativehemodynamicparametersandcreatininelevelswithearlygraftfunctionfollowinglivingdonorkidneytransplantationaretrospectivestudy AT novitaintanarovah associationofintraoperativehemodynamicparametersandcreatininelevelswithearlygraftfunctionfollowinglivingdonorkidneytransplantationaretrospectivestudy |