Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis
Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4′-bipyridine (BIP), 3-aminopyridine (3AP) and 4-hydroxyp...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/3834368 |
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| _version_ | 1850224597693104128 |
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| author | Lei Gao Xianrui Zhang |
| author_facet | Lei Gao Xianrui Zhang |
| author_sort | Lei Gao |
| collection | DOAJ |
| description | Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4′-bipyridine (BIP), 3-aminopyridine (3AP) and 4-hydroxypyridine (4HP), were designed to improve the solubility of FEB. The single-crystal structures were elucidated, and their physical and chemical properties were investigated by IR, PXRD, and DSC. In addition, drug-related properties, including the solubility and powder dissolution rate were assessed. The solubility and powder dissolution studies showed that the FEB-BIP cocrystal and FEB-3AP salt have superior dissolution compared to FEB. |
| format | Article |
| id | doaj-art-4eb0696ffe6d468e95aab51ccece583f |
| institution | OA Journals |
| issn | 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-4eb0696ffe6d468e95aab51ccece583f2025-08-20T02:05:35ZengWileyJournal of Chemistry2090-90712021-01-01202110.1155/2021/3834368Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties AnalysisLei Gao0Xianrui Zhang1College of Chemical Engineering and Resource RecyclingCollege of Chemical Engineering and Resource RecyclingDrug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4′-bipyridine (BIP), 3-aminopyridine (3AP) and 4-hydroxypyridine (4HP), were designed to improve the solubility of FEB. The single-crystal structures were elucidated, and their physical and chemical properties were investigated by IR, PXRD, and DSC. In addition, drug-related properties, including the solubility and powder dissolution rate were assessed. The solubility and powder dissolution studies showed that the FEB-BIP cocrystal and FEB-3AP salt have superior dissolution compared to FEB.http://dx.doi.org/10.1155/2021/3834368 |
| spellingShingle | Lei Gao Xianrui Zhang Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis Journal of Chemistry |
| title | Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis |
| title_full | Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis |
| title_fullStr | Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis |
| title_full_unstemmed | Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis |
| title_short | Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis |
| title_sort | cocrystallization of febuxostat with pyridine coformers crystal structural and physicochemical properties analysis |
| url | http://dx.doi.org/10.1155/2021/3834368 |
| work_keys_str_mv | AT leigao cocrystallizationoffebuxostatwithpyridinecoformerscrystalstructuralandphysicochemicalpropertiesanalysis AT xianruizhang cocrystallizationoffebuxostatwithpyridinecoformerscrystalstructuralandphysicochemicalpropertiesanalysis |