Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish
The toxicity of tris (2-butoxyethyl) phosphate (TBOEP) has been extensively investigated because of its prevalence in the environment. Nevertheless, the risk factors associated with maternal transmission are poorly understood. In this study, sexually mature female zebrafish were treated with TBOEP (...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001174 |
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| author | Anqi Dong Wenqian Lei Weiqi Zhou Wenwen Li Jianghua Wang |
| author_facet | Anqi Dong Wenqian Lei Weiqi Zhou Wenwen Li Jianghua Wang |
| author_sort | Anqi Dong |
| collection | DOAJ |
| description | The toxicity of tris (2-butoxyethyl) phosphate (TBOEP) has been extensively investigated because of its prevalence in the environment. Nevertheless, the risk factors associated with maternal transmission are poorly understood. In this study, sexually mature female zebrafish were treated with TBOEP (0, 20, 100, and 500 μg/L) for 30 days and were mated with unexposed males. Reproduction impairment in exposed adults (F0), including retarded gonado-somatic index (GSI), delayed oocyte maturation, inhibition of reproductive behavior, and subfertility was found. The observed impacts on the F0 generation were linked to a marked decrease in 17β-estradiol concentrations and disruptions in the gene expression patterns along the hypothalamic-pituitary-gonadal-liver (HPGL) axis. Moreover, the accumulation of TBOEP in F0 and their embryos (F1) was observed, indicating significant maternal transfer of TBOEP to the offspring. In F1 larvae, a dose-dependent increase in developmental toxicity (decreased heart rate and swimming behavior, increased larval mortality, and deformity) was observed. Additionally, a notable reduction in protein level in eggs and the gene expression of both the hormone/insulin-like growth factor (GH/IGF) and hypothalamic-pituitary-thyroid (HPT) pathways were observed. These results indicated that subacute TBOEP exposure could induce reproductive toxicity in female zebrafish and cause transgenerational toxicity in their offspring via maternal transfer. |
| format | Article |
| id | doaj-art-4eadda761b67431084c8bebdbe71f354 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-4eadda761b67431084c8bebdbe71f3542025-02-12T05:30:20ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117781Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafishAnqi Dong0Wenqian Lei1Weiqi Zhou2Wenwen Li3Jianghua Wang4Fisheries College, Huazhong Agricultural University, Wuhan 430070, ChinaFisheries College, Huazhong Agricultural University, Wuhan 430070, ChinaFisheries College, Huazhong Agricultural University, Wuhan 430070, ChinaFisheries College, Huazhong Agricultural University, Wuhan 430070, ChinaFisheries College, Huazhong Agricultural University, Wuhan 430070, China; Hubei Engineering Technology Research Center for Aquatic Animal Disease Control and Prevention, Wuhan 430070, China; Corresponding author at: Fisheries College, Huazhong Agricultural University, Wuhan 430070, China.The toxicity of tris (2-butoxyethyl) phosphate (TBOEP) has been extensively investigated because of its prevalence in the environment. Nevertheless, the risk factors associated with maternal transmission are poorly understood. In this study, sexually mature female zebrafish were treated with TBOEP (0, 20, 100, and 500 μg/L) for 30 days and were mated with unexposed males. Reproduction impairment in exposed adults (F0), including retarded gonado-somatic index (GSI), delayed oocyte maturation, inhibition of reproductive behavior, and subfertility was found. The observed impacts on the F0 generation were linked to a marked decrease in 17β-estradiol concentrations and disruptions in the gene expression patterns along the hypothalamic-pituitary-gonadal-liver (HPGL) axis. Moreover, the accumulation of TBOEP in F0 and their embryos (F1) was observed, indicating significant maternal transfer of TBOEP to the offspring. In F1 larvae, a dose-dependent increase in developmental toxicity (decreased heart rate and swimming behavior, increased larval mortality, and deformity) was observed. Additionally, a notable reduction in protein level in eggs and the gene expression of both the hormone/insulin-like growth factor (GH/IGF) and hypothalamic-pituitary-thyroid (HPT) pathways were observed. These results indicated that subacute TBOEP exposure could induce reproductive toxicity in female zebrafish and cause transgenerational toxicity in their offspring via maternal transfer.http://www.sciencedirect.com/science/article/pii/S0147651325001174Organophosporus flame retardantsReproductive toxicityMaternal transferFemale zebrafishDevelopmental toxicity |
| spellingShingle | Anqi Dong Wenqian Lei Weiqi Zhou Wenwen Li Jianghua Wang Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish Ecotoxicology and Environmental Safety Organophosporus flame retardants Reproductive toxicity Maternal transfer Female zebrafish Developmental toxicity |
| title | Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| title_full | Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| title_fullStr | Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| title_full_unstemmed | Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| title_short | Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| title_sort | maternal exposure to tris 2 butoxyethyl phosphate induces f0 female reproductive toxicity and offspring developmental toxicity in zebrafish |
| topic | Organophosporus flame retardants Reproductive toxicity Maternal transfer Female zebrafish Developmental toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001174 |
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