The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea
BackgroundDespite a high tuberculosis incidence in Korea, the association between tuberculosis and depression remains underexplored. This study aims to assess depression risk in tuberculosis survivors.MethodsUtilizing South Korea’s National Health Insurance Sharing Service (NHISS) database, we condu...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1425637/full |
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| author | Hyun Soo Kim Jin Hyung Jung Kyungdo Han Hyewon Kim Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon |
| author_facet | Hyun Soo Kim Jin Hyung Jung Kyungdo Han Hyewon Kim Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon |
| author_sort | Hyun Soo Kim |
| collection | DOAJ |
| description | BackgroundDespite a high tuberculosis incidence in Korea, the association between tuberculosis and depression remains underexplored. This study aims to assess depression risk in tuberculosis survivors.MethodsUtilizing South Korea’s National Health Insurance Sharing Service (NHISS) database, we conducted a gender-age-matched analysis comparing depression risk between tuberculosis survivors and the general population.ResultsThis study included 137,996 participants, of whom 34,499 had tuberculosis history, and 103,497 age- and sex-matched individuals were selected as the control group. The risk of developing depression was higher in tuberculosis survivors than in the control group (aHR 1.20, 95% CI 1.15-1.25). In men, the risk of developing depression was 1.32 times (95% CI 1.25-1.39) compared with 1.05 times (95% CI 0.98-1.12) in women. Those taking para-aminosalicylate, cycloserine, and prothionamide had a higher risk of developing depression compared to those using other anti-tuberculosis drugs, with the risk ratio ranging from 1.27 to 1.61.ConclusionTuberculosis survivors had a higher risk of developing depression compared to the control group. Although the prevalence of depression was higher in women compared to men, the risk of developing depression was higher in male tuberculosis survivors than in the control group, in contrast to the findings in women. The risk of developing depression in tuberculosis survivors differed depending on the anti-tuberculosis drug used and was mainly high in most of the second-line anti-tuberculosis drugs. |
| format | Article |
| id | doaj-art-4eab153ab5a04315b681d57f00402e2f |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-4eab153ab5a04315b681d57f00402e2f2025-08-20T03:01:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-02-011610.3389/fpsyt.2025.14256371425637The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South KoreaHyun Soo Kim0Jin Hyung Jung1Kyungdo Han2Hyewon Kim3Hong Jin Jeon4Hong Jin Jeon5Hong Jin Jeon6Hong Jin Jeon7Department of Psychiatry, Dong-A University College of Medicine, Busan, Republic of KoreaDepartment of Biostatistics, College of Medicine, Catholic University of Korea, Seoul, Republic of KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of KoreaDepartment of Psychiatry, Hallym University Sacred Heart Hospital, Anyang, Republic of KoreaDepartment of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Health Sciences & Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of KoreaDepartment of Medical Device Management & Research, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of KoreaDepartment of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of KoreaBackgroundDespite a high tuberculosis incidence in Korea, the association between tuberculosis and depression remains underexplored. This study aims to assess depression risk in tuberculosis survivors.MethodsUtilizing South Korea’s National Health Insurance Sharing Service (NHISS) database, we conducted a gender-age-matched analysis comparing depression risk between tuberculosis survivors and the general population.ResultsThis study included 137,996 participants, of whom 34,499 had tuberculosis history, and 103,497 age- and sex-matched individuals were selected as the control group. The risk of developing depression was higher in tuberculosis survivors than in the control group (aHR 1.20, 95% CI 1.15-1.25). In men, the risk of developing depression was 1.32 times (95% CI 1.25-1.39) compared with 1.05 times (95% CI 0.98-1.12) in women. Those taking para-aminosalicylate, cycloserine, and prothionamide had a higher risk of developing depression compared to those using other anti-tuberculosis drugs, with the risk ratio ranging from 1.27 to 1.61.ConclusionTuberculosis survivors had a higher risk of developing depression compared to the control group. Although the prevalence of depression was higher in women compared to men, the risk of developing depression was higher in male tuberculosis survivors than in the control group, in contrast to the findings in women. The risk of developing depression in tuberculosis survivors differed depending on the anti-tuberculosis drug used and was mainly high in most of the second-line anti-tuberculosis drugs.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1425637/fulltuberculosisgender differencedepressionanti-tuberculosis drugscycloserine |
| spellingShingle | Hyun Soo Kim Jin Hyung Jung Kyungdo Han Hyewon Kim Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon Hong Jin Jeon The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea Frontiers in Psychiatry tuberculosis gender difference depression anti-tuberculosis drugs cycloserine |
| title | The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea |
| title_full | The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea |
| title_fullStr | The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea |
| title_full_unstemmed | The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea |
| title_short | The risk of developing depression in tuberculosis survivors: a nationwide cohort study in South Korea |
| title_sort | risk of developing depression in tuberculosis survivors a nationwide cohort study in south korea |
| topic | tuberculosis gender difference depression anti-tuberculosis drugs cycloserine |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1425637/full |
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