Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold
Abstract In this study, a porous Ti-25Ta alloy scaffold was fabricated using additive manufacturing(AM) and compared with pure Ti to evaluate its biocompatibility and osteogenic potential. The scaffolds were fabricated using a Laser Beam Powder Bed Fusion process, followed by investigations of physi...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Applied Sciences |
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| Online Access: | https://doi.org/10.1007/s42452-025-07367-6 |
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| author | Di Wu Yada Li Wangwei Zhu Haolin Jiao Bing Ge Qinwen Xie Jianfeng Xu Weidan Wang Fang Cao Guangxiao Yin Junlei Li Dewei Zhao |
| author_facet | Di Wu Yada Li Wangwei Zhu Haolin Jiao Bing Ge Qinwen Xie Jianfeng Xu Weidan Wang Fang Cao Guangxiao Yin Junlei Li Dewei Zhao |
| author_sort | Di Wu |
| collection | DOAJ |
| description | Abstract In this study, a porous Ti-25Ta alloy scaffold was fabricated using additive manufacturing(AM) and compared with pure Ti to evaluate its biocompatibility and osteogenic potential. The scaffolds were fabricated using a Laser Beam Powder Bed Fusion process, followed by investigations of physical properties, in vitro cytocompatibility, osteogenesis, macrophage polarization, and in vivo bone reconstruction. Pure Ti exhibits the highest wettability, cell proliferation, osteogenic differentiation, mineralized nodule formation, anti-inflammatory capability, and bone reconstruction. The adoption of Ta in the Ti-25Ta alloy significantly increases its wettability, osteogenesis, and anti-inflammatory without a great increase in density. In summary, the Ti-25Ta alloy has a favorable balance of physical properties and biological performance, making it a promising candidate as a bone implant material. |
| format | Article |
| id | doaj-art-4ea52de0e87b4c2a8711fa07dcb755cb |
| institution | DOAJ |
| issn | 3004-9261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Applied Sciences |
| spelling | doaj-art-4ea52de0e87b4c2a8711fa07dcb755cb2025-08-20T03:05:55ZengSpringerDiscover Applied Sciences3004-92612025-07-017711810.1007/s42452-025-07367-6Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffoldDi Wu0Yada Li1Wangwei Zhu2Haolin Jiao3Bing Ge4Qinwen Xie5Jianfeng Xu6Weidan Wang7Fang Cao8Guangxiao Yin9Junlei Li10Dewei Zhao11Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian UniversityAbstract In this study, a porous Ti-25Ta alloy scaffold was fabricated using additive manufacturing(AM) and compared with pure Ti to evaluate its biocompatibility and osteogenic potential. The scaffolds were fabricated using a Laser Beam Powder Bed Fusion process, followed by investigations of physical properties, in vitro cytocompatibility, osteogenesis, macrophage polarization, and in vivo bone reconstruction. Pure Ti exhibits the highest wettability, cell proliferation, osteogenic differentiation, mineralized nodule formation, anti-inflammatory capability, and bone reconstruction. The adoption of Ta in the Ti-25Ta alloy significantly increases its wettability, osteogenesis, and anti-inflammatory without a great increase in density. In summary, the Ti-25Ta alloy has a favorable balance of physical properties and biological performance, making it a promising candidate as a bone implant material.https://doi.org/10.1007/s42452-025-07367-6AMTi-25Ta alloyPorous scaffoldBiocompatibility |
| spellingShingle | Di Wu Yada Li Wangwei Zhu Haolin Jiao Bing Ge Qinwen Xie Jianfeng Xu Weidan Wang Fang Cao Guangxiao Yin Junlei Li Dewei Zhao Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold Discover Applied Sciences AM Ti-25Ta alloy Porous scaffold Biocompatibility |
| title | Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold |
| title_full | Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold |
| title_fullStr | Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold |
| title_full_unstemmed | Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold |
| title_short | Fabrication and biocompatibility of a 3D-printed porous Ti-25Ta alloy scaffold |
| title_sort | fabrication and biocompatibility of a 3d printed porous ti 25ta alloy scaffold |
| topic | AM Ti-25Ta alloy Porous scaffold Biocompatibility |
| url | https://doi.org/10.1007/s42452-025-07367-6 |
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