Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes
Abstract Background This prospective study evaluated the efficacy of 3D-printed personalized vertebral implants in restoring spinal stability following total en bloc spondylectomy (TES) for benign spinal tumors. Given the lack of specialized implants for post-resection reconstruction, this approach...
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BMC
2025-08-01
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| Series: | 3D Printing in Medicine |
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| Online Access: | https://doi.org/10.1186/s41205-025-00294-7 |
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| author | Viktor G. Aleinikov Talgat T. Kerimbayev Yergen N. Kenzhegulov Daniyar K. Zhamoldin Zhandos M. Tuigynov Ermek A. Urunbayev Nurzhan B. Abishev Meirzhan S. Oshayev Dinara M. Baiskhanova Makar P. Solodovnikov Serik K. Akshulakov Diana Kerimbayeva |
| author_facet | Viktor G. Aleinikov Talgat T. Kerimbayev Yergen N. Kenzhegulov Daniyar K. Zhamoldin Zhandos M. Tuigynov Ermek A. Urunbayev Nurzhan B. Abishev Meirzhan S. Oshayev Dinara M. Baiskhanova Makar P. Solodovnikov Serik K. Akshulakov Diana Kerimbayeva |
| author_sort | Viktor G. Aleinikov |
| collection | DOAJ |
| description | Abstract Background This prospective study evaluated the efficacy of 3D-printed personalized vertebral implants in restoring spinal stability following total en bloc spondylectomy (TES) for benign spinal tumors. Given the lack of specialized implants for post-resection reconstruction, this approach integrates customized 3D-printed implants to enhance the anatomical precision, biomechanical stability, and clinical outcomes. Methods Four patients underwent TES using custom-designed 3D-printed vertebral implants. Key surgical parameters including operative time, intraoperative blood loss, pain reduction (VAS), and functional recovery (ODI) were assessed. Biomechanical testing was conducted to evaluate implant durability under high loads. Functional and neurological outcomes were monitored over a two-year follow-up period using clinical assessments and CT imaging. Results Personalized 3D-printed implants demonstrated high mechanical stability with no structural deformation under load-bearing conditions. Postoperative VAS and ODI scores significantly improved, indicating substantial pain reduction and enhanced functional recovery. Neurological evaluations revealed that 75% of patients regained full motor and sensory functions. CT imaging confirmed stable implant positioning, with no signs of subsidence, fixation failure, or implant-related complications. Conclusions This study highlights the clinical feasibility and potential advantages of 3D-printed personalized vertebral implants for spinal reconstruction, including optimized surgical planning, reduced operative time, and minimal blood loss. Despite promising short-term outcomes, further large-scale, multicenter trials are required to establish long-term clinical efficacy and broader applicability in diverse patient populations. |
| format | Article |
| id | doaj-art-4ea0394cb71541a1a3e642d7930eb862 |
| institution | Kabale University |
| issn | 2365-6271 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | 3D Printing in Medicine |
| spelling | doaj-art-4ea0394cb71541a1a3e642d7930eb8622025-08-20T03:45:45ZengBMC3D Printing in Medicine2365-62712025-08-0111111510.1186/s41205-025-00294-7Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomesViktor G. Aleinikov0Talgat T. Kerimbayev1Yergen N. Kenzhegulov2Daniyar K. Zhamoldin3Zhandos M. Tuigynov4Ermek A. Urunbayev5Nurzhan B. Abishev6Meirzhan S. Oshayev7Dinara M. Baiskhanova8Makar P. Solodovnikov9Serik K. Akshulakov10Diana Kerimbayeva11Department of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryLaboratory of Molecular Gastroenterology and Tumor Biology, Institute for Experimental Cancer Research, Christian-Albrechts-University of KielDepartment of Research Management, National Centre for NeurosurgeryCEO, National Centre for NeurosurgeryDepartment of Spinal Surgery and Pathology of the Peripheral Nervous System, National Centre for NeurosurgeryAbstract Background This prospective study evaluated the efficacy of 3D-printed personalized vertebral implants in restoring spinal stability following total en bloc spondylectomy (TES) for benign spinal tumors. Given the lack of specialized implants for post-resection reconstruction, this approach integrates customized 3D-printed implants to enhance the anatomical precision, biomechanical stability, and clinical outcomes. Methods Four patients underwent TES using custom-designed 3D-printed vertebral implants. Key surgical parameters including operative time, intraoperative blood loss, pain reduction (VAS), and functional recovery (ODI) were assessed. Biomechanical testing was conducted to evaluate implant durability under high loads. Functional and neurological outcomes were monitored over a two-year follow-up period using clinical assessments and CT imaging. Results Personalized 3D-printed implants demonstrated high mechanical stability with no structural deformation under load-bearing conditions. Postoperative VAS and ODI scores significantly improved, indicating substantial pain reduction and enhanced functional recovery. Neurological evaluations revealed that 75% of patients regained full motor and sensory functions. CT imaging confirmed stable implant positioning, with no signs of subsidence, fixation failure, or implant-related complications. Conclusions This study highlights the clinical feasibility and potential advantages of 3D-printed personalized vertebral implants for spinal reconstruction, including optimized surgical planning, reduced operative time, and minimal blood loss. Despite promising short-term outcomes, further large-scale, multicenter trials are required to establish long-term clinical efficacy and broader applicability in diverse patient populations.https://doi.org/10.1186/s41205-025-00294-73D printing in spine surgeryPersonalized spinal implantsSpinal tumor resectionTotal en bloc spondylectomy (TES)Vertebral reconstructionBiomechanical stability of implants |
| spellingShingle | Viktor G. Aleinikov Talgat T. Kerimbayev Yergen N. Kenzhegulov Daniyar K. Zhamoldin Zhandos M. Tuigynov Ermek A. Urunbayev Nurzhan B. Abishev Meirzhan S. Oshayev Dinara M. Baiskhanova Makar P. Solodovnikov Serik K. Akshulakov Diana Kerimbayeva Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes 3D Printing in Medicine 3D printing in spine surgery Personalized spinal implants Spinal tumor resection Total en bloc spondylectomy (TES) Vertebral reconstruction Biomechanical stability of implants |
| title | Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes |
| title_full | Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes |
| title_fullStr | Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes |
| title_full_unstemmed | Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes |
| title_short | Biomechanical and clinical evaluation of 3D-printed personalized vertebral implants after total En-Bloc spondylectomy: two-year follow-up outcomes |
| title_sort | biomechanical and clinical evaluation of 3d printed personalized vertebral implants after total en bloc spondylectomy two year follow up outcomes |
| topic | 3D printing in spine surgery Personalized spinal implants Spinal tumor resection Total en bloc spondylectomy (TES) Vertebral reconstruction Biomechanical stability of implants |
| url | https://doi.org/10.1186/s41205-025-00294-7 |
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