Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease
Abstract Post-discharge management of coronary artery disease (CAD) remains clinically challenging, with digital healthcare’s efficacy underexplored. This study analyzed 16,797 CAD patients enrolled in the HeartMed Digital Management System (June 2018–September 2022), comparing outcomes between a di...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-025-01655-6 |
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| author | Lanshu Yang Zuoxiang Wang Sheng Zhao Mengyuan Liu Yalin Zhu Fenghuan Hu Xiaojin Gao Yongjian Wu |
| author_facet | Lanshu Yang Zuoxiang Wang Sheng Zhao Mengyuan Liu Yalin Zhu Fenghuan Hu Xiaojin Gao Yongjian Wu |
| author_sort | Lanshu Yang |
| collection | DOAJ |
| description | Abstract Post-discharge management of coronary artery disease (CAD) remains clinically challenging, with digital healthcare’s efficacy underexplored. This study analyzed 16,797 CAD patients enrolled in the HeartMed Digital Management System (June 2018–September 2022), comparing outcomes between a digital management (DM, n = 4,713) and conventional management (CM, n = 12,084) cohort over 12 months. Cox models adjusted for confounders revealed significantly reduced all-cause mortality in the DM group (1.6% vs. 2.7%; HR 0.58, 95% CI 0.45–0.75, p < 0.001) and lower risks for major adverse cardiovascular events (MACCE: 6.4% vs. 9.2%; HR 0.67, 0.59–0.77, p < 0.001), cardiovascular death (HR 0.70, 0.51–0.95), myocardial infarction (HR 0.38, 0.29–0.50), recurrent angina (HR 0.75, 0.65–0.87), revascularization (HR 0.84, 0.71–0.99), and readmissions (HR 0.76, 0.68–0.84) (p < 0.05 for all). Digital healthcare demonstrates superior post-discharge optimization of CAD outcomes, significantly attenuating mortality and morbidity. |
| format | Article |
| id | doaj-art-4e9ec50b7a2c452f9bd2d5ed44619a0d |
| institution | DOAJ |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-4e9ec50b7a2c452f9bd2d5ed44619a0d2025-08-20T03:06:08ZengNature Portfolionpj Digital Medicine2398-63522025-07-018111210.1038/s41746-025-01655-6Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery diseaseLanshu Yang0Zuoxiang Wang1Sheng Zhao2Mengyuan Liu3Yalin Zhu4Fenghuan Hu5Xiaojin Gao6Yongjian Wu7Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng DistrictAbstract Post-discharge management of coronary artery disease (CAD) remains clinically challenging, with digital healthcare’s efficacy underexplored. This study analyzed 16,797 CAD patients enrolled in the HeartMed Digital Management System (June 2018–September 2022), comparing outcomes between a digital management (DM, n = 4,713) and conventional management (CM, n = 12,084) cohort over 12 months. Cox models adjusted for confounders revealed significantly reduced all-cause mortality in the DM group (1.6% vs. 2.7%; HR 0.58, 95% CI 0.45–0.75, p < 0.001) and lower risks for major adverse cardiovascular events (MACCE: 6.4% vs. 9.2%; HR 0.67, 0.59–0.77, p < 0.001), cardiovascular death (HR 0.70, 0.51–0.95), myocardial infarction (HR 0.38, 0.29–0.50), recurrent angina (HR 0.75, 0.65–0.87), revascularization (HR 0.84, 0.71–0.99), and readmissions (HR 0.76, 0.68–0.84) (p < 0.05 for all). Digital healthcare demonstrates superior post-discharge optimization of CAD outcomes, significantly attenuating mortality and morbidity.https://doi.org/10.1038/s41746-025-01655-6 |
| spellingShingle | Lanshu Yang Zuoxiang Wang Sheng Zhao Mengyuan Liu Yalin Zhu Fenghuan Hu Xiaojin Gao Yongjian Wu Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease npj Digital Medicine |
| title | Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| title_full | Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| title_fullStr | Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| title_full_unstemmed | Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| title_short | Effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| title_sort | effectiveness of digital healthcare to improve clinical outcomes in discharged patients with coronary artery disease |
| url | https://doi.org/10.1038/s41746-025-01655-6 |
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