Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis
Objective To examine the performance in adults of the European Alliance of Associations for Rheumatology (EULAR)/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 classification criteria for IgA vasculitis (IgAV).Methods The EULAR/PReS/Ankara 2008 classification criteria for IgAV w...
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BMJ Publishing Group
2025-07-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/11/3/e005728.full |
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| author | Ömer Karadağ Seza Ozen Cristina Ponte Richard A Watts Raashid Ahmed Luqmani Peter C Grayson Peter A Merkel Ravi Suppiah Joanna C Robson Alexandra Audemard-Verger Selcan Demir Cemal Bes Yagmur Bayindir Katherine B Gribbons Bugu Bulat Fatih Yildirim |
| author_facet | Ömer Karadağ Seza Ozen Cristina Ponte Richard A Watts Raashid Ahmed Luqmani Peter C Grayson Peter A Merkel Ravi Suppiah Joanna C Robson Alexandra Audemard-Verger Selcan Demir Cemal Bes Yagmur Bayindir Katherine B Gribbons Bugu Bulat Fatih Yildirim |
| author_sort | Ömer Karadağ |
| collection | DOAJ |
| description | Objective To examine the performance in adults of the European Alliance of Associations for Rheumatology (EULAR)/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 classification criteria for IgA vasculitis (IgAV).Methods The EULAR/PReS/Ankara 2008 classification criteria for IgAV were applied to patients enrolled in an international observational cohort which included patients with IgAV and comparators with other forms of small-vessel and medium-vessel vasculitis. After the initial assessment of the performance of the criteria, possible revisions to increase the performance were tested. The revised criteria were then assessed in an independent validation cohort within a multicentre Turkish vasculitis registry.Results The dataset consisted of 178 IgAV cases and 1705 comparators. The Ankara 2008 criteria require skin involvement plus one of the following four criteria: abdominal pain, a biopsy showing IgA deposition, arthritis or arthralgia, or renal involvement (any haematuria and/or proteinuria). The specificity of the criteria improved when a positive test for anti-neutrophil cytoplasmic autoantibody or blood cryoglobulins was considered an exclusion criterion. The revised criteria had a sensitivity of 76.4% (95% CI 69.8% to 82.2%) and a specificity of 94.5% (95.0% CI 93.4% to 95.1%). In the validation set, the sensitivity and specificity of the revised criteria were 97.8% (95% CI 94.0% to 99.0%) and 85.0% (95.0% CI 78.0% to 90.0%), respectively.Conclusion The revised EULAR/PReS-endorsed Ankara 2008 IgAV classification criteria perform well in adults with IgAV and are appropriate for use in clinical research. |
| format | Article |
| id | doaj-art-4e9eb522e79c4199b3215d6b00c1f963 |
| institution | DOAJ |
| issn | 2056-5933 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-4e9eb522e79c4199b3215d6b00c1f9632025-08-20T02:47:03ZengBMJ Publishing GroupRMD Open2056-59332025-07-0111310.1136/rmdopen-2025-005728Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitisÖmer Karadağ0Seza Ozen1Cristina Ponte2Richard A Watts3Raashid Ahmed Luqmani4Peter C Grayson5Peter A Merkel6Ravi Suppiah7Joanna C Robson8Alexandra Audemard-Verger9Selcan Demir10Cemal Bes11Yagmur Bayindir12Katherine B Gribbons13Bugu Bulat14Fatih Yildirim15Department of Rheumatology, Hacettepe University, Ankara, TurkeyDepartment of Pediatric Rheumatology, Hacettepe University, Ankara, TurkeyRheumatology Department, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa, Lisbon, PortugalUniversity of East Anglia, Norwich, UKUniversity of Oxford, Oxford, UKNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USAUniversity of Pennsylvania, Philadelphia, Pennsylvania, USAAuckland District Health Board, Auckland, New ZealandUniversity of the West of England, Bristol, UKCentre Hospitalier Régional Universitaire de Tours, Tours, FranceDepartment of Pediatric Rheumatology, Eskisehir Osmangazi University, Eskisehir, TurkeyBaşakşehir Çam Sakura City Hospital, Department of Rheumatology, Istanbul, TurkeyDepartment of Pediatric Rheumatology, Hacettepe University, Ankara, TurkeyBrigham and Women’s Hospital, Boston, Massachusetts, USADepartment of Rheumatology, Hacettepe University, Ankara, TurkeyBaşakşehir Çam Sakura City Hospital, Department of Rheumatology, Istanbul, TurkeyObjective To examine the performance in adults of the European Alliance of Associations for Rheumatology (EULAR)/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 classification criteria for IgA vasculitis (IgAV).Methods The EULAR/PReS/Ankara 2008 classification criteria for IgAV were applied to patients enrolled in an international observational cohort which included patients with IgAV and comparators with other forms of small-vessel and medium-vessel vasculitis. After the initial assessment of the performance of the criteria, possible revisions to increase the performance were tested. The revised criteria were then assessed in an independent validation cohort within a multicentre Turkish vasculitis registry.Results The dataset consisted of 178 IgAV cases and 1705 comparators. The Ankara 2008 criteria require skin involvement plus one of the following four criteria: abdominal pain, a biopsy showing IgA deposition, arthritis or arthralgia, or renal involvement (any haematuria and/or proteinuria). The specificity of the criteria improved when a positive test for anti-neutrophil cytoplasmic autoantibody or blood cryoglobulins was considered an exclusion criterion. The revised criteria had a sensitivity of 76.4% (95% CI 69.8% to 82.2%) and a specificity of 94.5% (95.0% CI 93.4% to 95.1%). In the validation set, the sensitivity and specificity of the revised criteria were 97.8% (95% CI 94.0% to 99.0%) and 85.0% (95.0% CI 78.0% to 90.0%), respectively.Conclusion The revised EULAR/PReS-endorsed Ankara 2008 IgAV classification criteria perform well in adults with IgAV and are appropriate for use in clinical research.https://rmdopen.bmj.com/content/11/3/e005728.full |
| spellingShingle | Ömer Karadağ Seza Ozen Cristina Ponte Richard A Watts Raashid Ahmed Luqmani Peter C Grayson Peter A Merkel Ravi Suppiah Joanna C Robson Alexandra Audemard-Verger Selcan Demir Cemal Bes Yagmur Bayindir Katherine B Gribbons Bugu Bulat Fatih Yildirim Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis RMD Open |
| title | Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis |
| title_full | Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis |
| title_fullStr | Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis |
| title_full_unstemmed | Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis |
| title_short | Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis |
| title_sort | performance in adults of the eular printo pres ankara 2008 classification criteria for iga vasculitis |
| url | https://rmdopen.bmj.com/content/11/3/e005728.full |
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