Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 inflammasome mediated by gut microbiota

Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 inflammasome mediated by gut microbiota

Abstract Background Huanglian Jiedu Decoction (HLJDD) is a representative formula for clearing heat and removing toxins, and some basic studies indicated that it can improve the learning cognitive ability of Alzheimer’s disease (AD) mice, but the underlying molecular mechanism of its improvement in...

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Bibliographic Details
Main Authors: Yani Zhang, Jiahua Wang, Xuetao Li, Ruibo Guo, Liyan Wang, Yang Liu, Yang Yu, Liang Kong
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Chinese Medicine
Subjects:
Huanglian Jiedu Decoction
Alzheimer’s disease
Gut microbiota
NLRP3
Online Access:https://doi.org/10.1186/s13020-025-01180-4
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