Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled
Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection. Other protozoa parasites with brain tropism include Toxoplasma, Plasmodium, Amoeba, and, eventually, o...
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Shared Science Publishers OG
2021-04-01
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| Online Access: | http://microbialcell.com/researcharticles/2021a-figarella-microbial-cell/ |
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| author | Katherine Figarella |
| author_facet | Katherine Figarella |
| author_sort | Katherine Figarella |
| collection | DOAJ |
| description | Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection. Other protozoa parasites with brain tropism include Toxoplasma, Plasmodium, Amoeba, and, eventually, other Trypano-somatids such as T. cruzi and Leishmania. Together, these parasites affect billions of people worldwide and are responsible for more than 500.000 deaths annually. Factors determining brain tropism, mechanisms of in-vasion as well as processes ongoing inside the brain are not well understood. But, they depend on the par-asite involved. The pathogenesis caused by T. brucei initiates locally in the area of parasite inoculation, soon trypanosomes rich the blood, and the disease enters in the so-called early stage. The pathomecha-nisms in this phase have been described, even mole-cules used to combat the disease are effective during this period. Later, the disease evolves towards a late-stage, characterized by the presence of parasites in the central nervous system (CNS), the so-called meningo-encephalitic stage. This phase of the disease has not been sufficiently examined and remains a matter of investigation. Here, I stress the importance of delve into the study of the neuropathogenesis caused by T. brucei, which will enable the identification of path-ways that may be targeted to overcome parasites that reached the CNS. Finally, I highlight the impact that the application of tools developed in the last years in the field of neuroscience will have on the study of neglect-ed tropical diseases. |
| format | Article |
| id | doaj-art-4e9c619a32c84847a5488812e5382d4e |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Shared Science Publishers OG |
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| series | Microbial Cell |
| spelling | doaj-art-4e9c619a32c84847a5488812e5382d4e2025-08-20T02:57:39ZengShared Science Publishers OGMicrobial Cell2311-26382021-04-0184737610.15698/mic2021.04.745Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiledKatherine Figarella0Department of Neurophysiology, Institute of Physiology, University of Tübingen, Germany.Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection. Other protozoa parasites with brain tropism include Toxoplasma, Plasmodium, Amoeba, and, eventually, other Trypano-somatids such as T. cruzi and Leishmania. Together, these parasites affect billions of people worldwide and are responsible for more than 500.000 deaths annually. Factors determining brain tropism, mechanisms of in-vasion as well as processes ongoing inside the brain are not well understood. But, they depend on the par-asite involved. The pathogenesis caused by T. brucei initiates locally in the area of parasite inoculation, soon trypanosomes rich the blood, and the disease enters in the so-called early stage. The pathomecha-nisms in this phase have been described, even mole-cules used to combat the disease are effective during this period. Later, the disease evolves towards a late-stage, characterized by the presence of parasites in the central nervous system (CNS), the so-called meningo-encephalitic stage. This phase of the disease has not been sufficiently examined and remains a matter of investigation. Here, I stress the importance of delve into the study of the neuropathogenesis caused by T. brucei, which will enable the identification of path-ways that may be targeted to overcome parasites that reached the CNS. Finally, I highlight the impact that the application of tools developed in the last years in the field of neuroscience will have on the study of neglect-ed tropical diseases.http://microbialcell.com/researcharticles/2021a-figarella-microbial-cell/trypanosomaanti-trypanosomatid drugsmeningoencephalitisneuropathogenesistwo-photon microscopy |
| spellingShingle | Katherine Figarella Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled Microbial Cell trypanosoma anti-trypanosomatid drugs meningoencephalitis neuropathogenesis two-photon microscopy |
| title | Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled |
| title_full | Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled |
| title_fullStr | Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled |
| title_full_unstemmed | Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled |
| title_short | Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled |
| title_sort | neuropathogenesis caused by trypanosoma brucei still an enigma to be unveiled |
| topic | trypanosoma anti-trypanosomatid drugs meningoencephalitis neuropathogenesis two-photon microscopy |
| url | http://microbialcell.com/researcharticles/2021a-figarella-microbial-cell/ |
| work_keys_str_mv | AT katherinefigarella neuropathogenesiscausedbytrypanosomabruceistillanenigmatobeunveiled |