Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration

Abstract Background Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods We employed an integrative imaging transcriptomi...

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Main Authors: Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Neurodegeneration
Subjects:
Behavioral variant frontotemporal dementia
Transcriptomics
Cortical thickness
Partial least squares regression
Synaptic density
Pathology
Online Access:https://doi.org/10.1186/s13024-025-00806-3
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