The role of RGS12 in tissue repair and human diseases
Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it ha...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224002770 |
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| author | Min Jiang Hongmei Li Qiong Zhang Tongtong Xu Le Huang Jinghong Zhang Huiqing Yu Junhui Zhang |
| author_facet | Min Jiang Hongmei Li Qiong Zhang Tongtong Xu Le Huang Jinghong Zhang Huiqing Yu Junhui Zhang |
| author_sort | Min Jiang |
| collection | DOAJ |
| description | Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it has been found that RGS12 affects the activity of various cells in the human body, participates in many physiological and pathological processes, and plays an important role in the pathogenesis of many diseases. Here, we set out to comprehensively review the role of RGS12 in human diseases and its mechanisms, highlighting the possibility of RGS12 as a therapeutic target for the treatment of human diseases. |
| format | Article |
| id | doaj-art-4e9b65d8460b461d870f20e0fdd10870 |
| institution | OA Journals |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-4e9b65d8460b461d870f20e0fdd108702025-08-20T02:11:26ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-07-0112410148010.1016/j.gendis.2024.101480The role of RGS12 in tissue repair and human diseasesMin Jiang0Hongmei Li1Qiong Zhang2Tongtong Xu3Le Huang4Jinghong Zhang5Huiqing Yu6Junhui Zhang7Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China; Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, ChinaDepartment of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaInstitute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaGeneral Department of Critical Care Medicine, Zhenjiang Traditional Chinese Medicine Hospital, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Zhenjiang, Jiangsu 212003, ChinaArmy 72nd Group Military Hospital, Huzhou, Zhejiang 313000, ChinaDepartment of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China; Corresponding author. Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China.Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China; Corresponding author. Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China.Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it has been found that RGS12 affects the activity of various cells in the human body, participates in many physiological and pathological processes, and plays an important role in the pathogenesis of many diseases. Here, we set out to comprehensively review the role of RGS12 in human diseases and its mechanisms, highlighting the possibility of RGS12 as a therapeutic target for the treatment of human diseases.http://www.sciencedirect.com/science/article/pii/S2352304224002770CancerNervous disordersOsteoporosisRGS12Tissue repair |
| spellingShingle | Min Jiang Hongmei Li Qiong Zhang Tongtong Xu Le Huang Jinghong Zhang Huiqing Yu Junhui Zhang The role of RGS12 in tissue repair and human diseases Genes and Diseases Cancer Nervous disorders Osteoporosis RGS12 Tissue repair |
| title | The role of RGS12 in tissue repair and human diseases |
| title_full | The role of RGS12 in tissue repair and human diseases |
| title_fullStr | The role of RGS12 in tissue repair and human diseases |
| title_full_unstemmed | The role of RGS12 in tissue repair and human diseases |
| title_short | The role of RGS12 in tissue repair and human diseases |
| title_sort | role of rgs12 in tissue repair and human diseases |
| topic | Cancer Nervous disorders Osteoporosis RGS12 Tissue repair |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224002770 |
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