Repurposing of an inotropic drug dobutamine to enhance the production of human hematopoietic stem cells from human induced pluripotent stem cells

Repurposing of an inotropic drug dobutamine to enhance the production of human hematopoietic stem cells from human induced pluripotent stem cells

Abstract Background Dobutamine hydrochloride (DH), a common inotropic drug used for heart failure, has recently been discovered to inhibit Yes-Associated Protein (YAP). YAP is a key component of the Hippo signaling pathway and plays a crucial role in the regulation of hematopoietic cell growth. The...

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Bibliographic Details
Main Authors: Chuti Laowtammathron, Pimonwan Srisook, Pakpoom Kheolamai, Rangsun Parnpai, Chanchao Lorthongpanich, Surapol Issaragrisil
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Dobutamine hydrochloride
YAP
iPSCs
Hematopoietic stem cells
Hippo pathway
Online Access:https://doi.org/10.1186/s13287-025-04427-x
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